SAB3500952

Anti-IL-37 antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: predicted mol wt 24 kDa
• reatividade de espécies: human
• concentração: 1 mg/mL
• técnica(s): ELISA: suitable; immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• nº de adesão NCBI: NP_055254
• nº de adesão UniProt: Q9NZH6
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... IL37(27178)

Descrição

Descrição geral

IL-37 (interleukin 37) is an anti-inflammatory cytokine and is also termed as IL-1 family member 7 (IL-1F7). IL-37 belongs to the IL-1 cytokine family. This protein is expressed in blood monocytes, endothelial cells, adipocytes and epithelial cells. IL-37 is located on human chromosome 2q12.

Imunogênio

Antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.

Ações bioquímicas/fisiológicas

IL-37 (interleukin 37) acts as a suppressor for innate immunity and acquired immunity. IL-37 participates in the immunosuppressive property of human CD4⁺CD25⁺ regulatory T cells. It represses the synthesis of several pro-inflammatory cytokines like IL-1α, IL-1β, IL-6, IL-12, granulocyte colony-stimulating factor (G-SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and TNF-α (tumor necrosis factor alpha). It plays an important role in adaptive immunity.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligação

The action of this antibody can be blocked using blocking peptide SBP3500952.

forma física

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable