SAB3500252

Anti-TIM-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-T cell immunoglobulin and mucin domain containing protein 1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: predicted mol wt 40 kDa
• reatividade de espécies: human, mouse
• técnica(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• nº de adesão NCBI: NP_036338
• nº de adesão UniProt: Q96D42
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... HAVCR1(26762)

Descrição

Descrição geral

Hepatitis A virus cellular receptor 1 (HAVCR1) or T-cell immunoglobulin and mucin protein (TIM-1) is a type 1 transmembrane glycoprotein. The protein is found in the apical membrane of cells. It is expressed in the kidney, testis and activated CD4⁺ T-cells. It possesses a six-cysteine immunoglobulin-like domain, a T/SP rich domain and two N-glycosylation sites. The TIM-1 gene is localized on human chromosome 5q33.2.

Imunogênio

TIM-1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human TIM-1.

Aplicação

Anti-TIM-1 antibody produced in rabbit has been used in immunofluorescence.

Ações bioquímicas/fisiológicas

Hepatitis A virus cellular receptor 1 (HAVCR1) regulates susceptibility to human immunodeficiency virus-1 (HIV-1) infection. It is upregulated in injured kidneys. HAVCR1 inhibits the activation of the Ga12 G-protein by blocking its association to GTP. Polymorphisms in the protein have been associated with immune dysfunction.

Características e benefícios

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Ligação

The action of this antibody can be blocked using blocking peptide SBP3500252.

forma física

Supplied in PBS with 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable