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S9944

Sigma-Aldrich

Sibutramine hydrochloride monohydrate

≥98% (HPLC), solid

Sinônimo(s):

1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil

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About This Item

Fórmula empírica (Notação de Hill):
C17H26ClN · HCl
Número CAS:
84485-00-7
Peso molecular:
316.31
Número MDL:
MFCD04039806
Código UNSPSC:
12352116
ID de substância PubChem:
329824638
NACRES:
NA.77

Ensaio

≥98% (HPLC)

Formulário

solid

controle de medicamentos

USDEA Schedule IV

condição de armazenamento

desiccated

cor

white

solubilidade

DMSO: >30 mg/mL
H2O: insoluble

originador

Abbott

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2

InChI

1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2

chave InChI

KFNNPQDSPLWLCX-UHFFFAOYSA-N

Informações sobre genes

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

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Aplicação

Sibutramine hydrochloride monohydrate was used as standard to screen dietary supplements for sibutramine using ion mobility spectrometer.1

Ações bioquímicas/fisiológicas

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI).
Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Características e benefícios

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
109K4605V
109K46051
109K4605
118K47011
118K4701

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Jamie D Dunn et al.
Journal of pharmaceutical and biomedical analysis, 54(3), 469-474 (2010-10-14)
In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine using hand-held ion mobility spectrometers with an analysis time of 15 s. Ion mobility spectrometry is a high-throughput
Cibele S Borges et al.
PloS one, 8(6), e66091-e66091 (2013-06-19)
Sperm acquire motility and fertility capacity during epididymal transit, under the control of androgens and sympathetic innervations. It is already known that the acceleration of epididymal sperm transit time can lead to lower sperm quality. In a previous work we
Hiroaki Yashiro et al.
PloS one, 11(11), e0166198-e0166198 (2016-11-11)
Obesity is now recognized as a state of chronic low-grade inflammation and is called as metabolic inflammation. Delta-5 desaturase (D5D) is an enzyme that metabolizes dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA). Thus, D5D inhibition increases DGLA (precursor to anti-inflammatory
Alexandre V Ivachtchenko et al.
Journal of Alzheimer's disease : JAD, 58(4), 1043-1063 (2017-05-28)
Discovery of 5-HT6 receptor subtype and its exclusive localization within the central nervous system led to extensive investigations of its role in Alzheimer's disease, schizophrenia, and obesity. In the present study, we present preclinical evaluation of a novel highly-potent and
Cristiani F Bortolatto et al.
Psychopharmacology, 232(13), 2239-2249 (2015-01-08)
The searching for safe and effective antiobesity drugs has been the subject of intense research. Previous studies have shown several pharmacological applications of organoselenium compounds; however, their possible anorectic-like actions have not been investigated. This study aims to investigate the
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