Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

View All Documentation

S8071

Sigma-Aldrich

Salvinorin A

≥98% (HPLC), solid

Sinônimo(s):

(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodechydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C23H28O8
Número CAS:
83729-01-5
Peso molecular:
432.46
Número MDL:
MFCD05664742
Código UNSPSC:
12352200
ID de substância PubChem:
24899776
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

controle de medicamentos

regulated under CDSA - not available from Sigma-Aldrich Canada

condição de armazenamento

protect from light

cor

white

solubilidade

DMSO: ≥10 mg/mL
ethanol: ~3 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c4ccoc4)C(=O)OC

InChI

1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

chave InChI

OBSYBRPAKCASQB-AGQYDFLVSA-N

Informações sobre genes

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)
rat ... Oprk1(29335)

Procurando produtos similares? Visita Guia de comparação de produtos

Aplicação

Salvinorin A was administered to rats to study effects on lactic acid-stimulated stretching.1

Ações bioquímicas/fisiológicas

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.

Características e benefícios

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Diansan Su et al.
Anesthesia and analgesia, 114(1), 200-204 (2011-11-15)
Cerebral hypoxia/ischemia during infant congenital heart surgery is not uncommon and may induce devastating neurologic disabilities persistent over the lifespan. Hypoxia/ischemia-induced cerebrovascular dysfunction is thought to be an important contributor to neurological damage. No pharmacological agents have been found to
Cécile Béguin et al.
Bioorganic & medicinal chemistry letters, 22(2), 1023-1026 (2011-12-30)
The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial
Melissa A Bodnar Willard et al.
Analytical and bioanalytical chemistry, 402(2), 843-850 (2011-12-14)
Salvia divinorum is a plant material that is of forensic interest due to the hallucinogenic nature of the active ingredient, salvinorin A. In this study, S. divinorum was extracted and spiked onto four different plant materials (S. divinorum, Salvia officinalis
Kimberly M Lovell et al.
Bioorganic & medicinal chemistry, 20(9), 3100-3110 (2012-04-03)
Modification of the furan ring of salvinorin A (1), the main active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. Conversion of the furan ring to an aldehyde at the C-12 position
Fang Ji et al.
Brain research, 1490, 95-100 (2012-10-30)
Since herkinorin is the first non-opioid mu agonist derived from salvinorin A that has the ability to induce cerebral vascular dilatation, we hypothesized that herkinorin could have similar vascular dilatation effect via the mu and kappa opioid receptors and the
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica