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S7001

Sigma-Aldrich

Strychnine hemisulfate salt

≥98.0%, suitable for ligand binding assays and NMR

Sinônimo(s):

Strychnidin-10-one sulfate (2:1)

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About This Item

Fórmula linear:
C21H22N2O2 · 1/2H2SO4
Número CAS:
60-41-3
Peso molecular:
383.45
Número CE:
200-477-7
Número MDL:
MFCD00068328
Código UNSPSC:
12352210
ID de substância PubChem:
329824573
NACRES:
NA.26

Nome do produto

Strychnine hemisulfate salt,

Ensaio

≥98.0%

Nível de qualidade

100

Formulário

powder

técnica(s)

NMR: suitable
ligand binding assay: suitable

cor

white to off-white

cadeia de caracteres SMILES

OS(O)(=O)=O.O=C1C[C@@H]2OCC=C3CN4CC[C@@]56[C@@H]4C[C@@H]3[C@@H]2[C@@H]5N1c7ccccc67.O=C8C[C@@H]9OCC=C%10CN%11CC[C@@]%12%13[C@@H]%11C[C@@H]%10[C@@H]9[C@@H]%12N8c%14ccccc%13%14

InChI

1S/2C21H22N2O2.H2O4S/c2*24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;1-5(2,3)4/h2*1-5,13,16-17,19-20H,6-11H2;(H2,1,2,3,4)/t2*13-,16-,17-,19-,20-,21+;/m00./s1

chave InChI

GOOCRIHPADOQAS-ZNUXJMJHSA-N

Categorias relacionadas

Ações bioquímicas/fisiológicas

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palavra indicadora

Danger

Frases de perigo

H300 + H330,H410

Classificações de perigo

Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
BGBC5598
MKBR9210V
MKBQ9201V
SLBF1283V
SLBC3001V

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Louise Adermark et al.
Frontiers in systems neuroscience, 5, 85-85 (2011-10-27)
The flow of cortical information through the basal ganglia is a complex spatiotemporal pattern of increased and decreased firing. The striatum is the biggest input nucleus to the basal ganglia and the aim of this study was to assess the
Mari Hondo et al.
PloS one, 6(9), e25076-e25076 (2011-09-29)
Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood. We confirmed the effects
Rong-Qing Chen et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(9), 1948-1958 (2011-05-20)
Glycine in the hippocampus can exert its effect on both synaptic NMDA receptors (NMDARs) and extrasynaptic functional glycine receptors (GlyRs) via distinct binding sites. Previous studies have reported that glycine induces long-term potentiation (LTP) through the activation of synaptic NMDARs.
Adam C Roberts et al.
PloS one, 14(4), e0214374-e0214374 (2019-04-05)
Zebrafish larvae have several biological features that make them useful for cellular investigations of the mechanisms underlying learning and memory. Of particular interest in this regard is a rapid escape, or startle, reflex possessed by zebrafish larvae; this reflex, the
PeiPei Chau et al.
Addiction biology, 16(4), 591-599 (2011-07-28)
Studies have indicated that the metabotropic glutamate receptor 5 (mGluR5) antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) decreases ethanol self-administration, and the same receptor type was also suggested to be involved in the mechanism of action of the anti-craving substance acamprosate. Our previous research

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