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S6272

Sigma-Aldrich

Substance P Fragment 1-7

≥97% (HPLC)

Sinônimo(s):

Arg-Pro-Lys-Pro-Gln-Gln-Phe

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About This Item

Fórmula empírica (Notação de Hill):
C41H65N13O10
Número CAS:
68060-49-1
Peso molecular:
900.04
Número MDL:
MFCD00076789
Código UNSPSC:
12352209
ID de substância PubChem:
24899694
NACRES:
NA.26

product name

Substance P Fragment 1-7, ≥97% (HPLC)

Ensaio

≥97% (HPLC)

forma

powder

composição

Peptide content, ≥65%

cor

white

nº de adesão UniProt

P20366

aplicação(ões)

cell analysis

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

NCCCCC(NC(=O)C1CCCN1C(=O)C(N)CCCNC(N)=N)C(=O)N2CCCC2C(=O)NC(CCC(N)=O)C(=O)NC(CCC(N)=O)C(=O)NC(Cc3ccccc3)C(O)=O

InChI

1S/C41H65N13O10/c42-19-5-4-12-28(51-37(60)30-13-7-21-53(30)38(61)25(43)11-6-20-48-41(46)47)39(62)54-22-8-14-31(54)36(59)50-27(16-18-33(45)56)34(57)49-26(15-17-32(44)55)35(58)52-29(40(63)64)23-24-9-2-1-3-10-24/h1-3,9-10,25-31H,4-8,11-23,42-43H2,(H2,44,55)(H2,45,56)(H,49,57)(H,50,59)(H,51,60)(H,52,58)(H,63,64)(H4,46,47,48)

chave InChI

KPHDBQWTCKBKIL-UHFFFAOYSA-N

Informações sobre genes

human ... TAC1(6863)

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe

Ações bioquímicas/fisiológicas

Fragment that gives depressor and bradycardic effects when applied to the nucleus tractus solitarius

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Anna Carlsson et al.
European journal of pharmacology, 626(2-3), 250-255 (2009-10-20)
We have recently explored the role of the tachykinin substance P neuroactive fragment substance P(1-7) in the mediation of anti-inflammatory effects using a blister model in the rat paw (Wiktelius et al., 2006). We observed that this heptapeptide induced a
Qin Zhou et al.
Peptides, 32(8), 1661-1665 (2011-07-19)
The N-terminal substance P fragment SP(1-7) is known to modulate hyperalgesia and opioid withdrawal in animal models. This study examined the effects of intraperitoneal (i.p.) injections of SP(1-7) on chronic morphine tolerance and on the levels of dynorphin B (DYN
Milad Botros et al.
Peptides, 27(4), 753-759 (2005-10-12)
Endomorphin-1 (EM-1) and endomorphin-2 (EM-2) represent two opioid active tetrapeptides with high affinity and selectivity for the mu-opioid (MOP) receptor. Both EM-1 and EM-2 exhibit strong inhibition of pain signals in the central nervous system (CNS). In contrast to these
Qin Zhou et al.
Peptides, 25(11), 1951-1957 (2004-10-27)
The aminoterminal fragment of substance P (SP), SP(1-7), has been suggested to modulate the expression of opiate tolerance and withdrawal behaviors in rodents. However, the mechanism of this effect is not yet clarified. Using a rat model we have previously
Qin Zhou et al.
Neuroscience letters, 320(3), 117-120 (2002-02-20)
The biologically active substance P (SP) N-terminal metabolite SP(1-7) has been reported to modulate several neural processes such as learning, locomotor activity and reaction to opioid withdrawal. Although all these processes are believed to be associated with dopaminergic transmission no
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