S6072

Anti-STIM1 (N-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): STIM1 Antibody - Anti-STIM1 (N-terminal) antibody produced in rabbit, Stim1 Antibody, Anti-GOK, Anti-Stromal interaction molecule I
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: antigen 90 kDa
• reatividade de espécies: rat, mouse, human
• validação aprimorada: independent; Learn more about Antibody Enhanced Validation
• concentração: ~1 mg/mL
• técnica(s): immunoprecipitation (IP): 2.5-5 μg using extracts of rat PC12 cells.; indirect immunofluorescence: 5-10 μg/mL using human HeLa cells.; western blot: 2-4 μg/mL using whole extract of mouse 3T3 cells.
• nº de adesão UniProt: Q13586
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... STIM1(6786) ; mouse ... Stim1(20866) ; rat ... Stim1(117086)

Descrição

Descrição geral

STIM1 (stromal interaction molecule 1) is a conserved single-pass transmembrane protein, which is expressed ubiquitously in a wide variety of human primary and transformed cell types. STIM1 is modified by phosphorylation and N-linked glycosylation. STIM1 localized predominantly in the membrane of the endoplasmic reticulum (ER). It contains an N-terminal EF hand motif located in the ER lumen and appears to function as a sensor of ER Ca²⁺ levels.

Imunogênio

synthetic peptide corresponding to amino acids 61-74 of human STIM1, conjugated to KLH via a C-terminal cysteine residue. The corresponding sequence is identical in rat and mouse.

Aplicação

Anti-STIM1 (N-terminal) antibody produced in rabbit has been used in:

• western blotting
• immunoprecipitation
• immunofluorescence

Ações bioquímicas/fisiológicas

STIM1 (stromal interaction molecule 1) is required for the activation of store-operated Ca²⁺ influx. Overexpression of STIM1 and Orai1 markedly increases the calcium release-activated calcium (CRAC) current (I-CRAC).

forma física

Solution in 0.01 M phosphate buffered saline, 7.4 pH, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)