S5951

SW02

• Sinônimo(s): 4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester
• Fórmula empírica (Notação de Hill): C₁₉H₂₃BrN₂O₅
• Número CAS: 1010820-68-4
• Peso molecular: 439.30
• Número MDL: MFCD17215960
• Código UNSPSC: 12352200
• ID de substância PubChem: 329824558
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to off-white
• solubilidade: DMSO: ≥20 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCOC(=O)C1=C(C)N(CCCC(=O)OC)C(=O)NC1c2ccc(Br)cc2
• InChI: 1S/C19H23BrN2O5/c1-4-27-18(24)16-12(2)22(11-5-6-15(23)26-3)19(25)21-17(16)13-7-9-14(20)10-8-13/h7-10,17H,4-6,11H2,1-3H3,(H,21,25)
• chave InChI: YFZRMRYVWWUQME-UHFFFAOYSA-N

Descrição

Aplicação

SW02 may be used in Hsp70-mediated cell signaling studies.

Ações bioquímicas/fisiológicas

SW02 is a specific activator/agonist of Hsp70. Hsp70 is of particular interest in diseases caused by protein misfolding, such as tau and Aβ in Alzheimer′s. SW02 increases Hsp70 ATPase activity, resulting in increased tau protein but not other disease-related proteins in cells. Hsp70 prevents aggregation of Aβ peptide, as shown by treatment with SW02.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable