S5576
SKA-31
≥98% (HPLC)
Sinônimo(s):
Naphtho[1,2-d]thiazol-2-ylamine
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About This Item
Fórmula empírica (Notação de Hill):
C11H8N2S
Número CAS:
Peso molecular:
200.26
Número MDL:
Código UNSPSC:
12352202
ID de substância PubChem:
NACRES:
NA.25
Produtos recomendados
Ensaio
≥98% (HPLC)
forma
solid
solubilidade
DMSO: ≥30 mg/mL
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
Nc1nc2c(ccc3ccccc23)s1
InChI
1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
chave InChI
FECQXVPRUCCUIL-UHFFFAOYSA-N
Ações bioquímicas/fisiológicas
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral - Eye Irrit. 2
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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The aim of this study was to investigate the hemodynamic effects of SKA-31, an activator of the small (KCa2.x) and intermediate (KCa3.1) conductance calcium-activated potassium channels, and to evaluate its influence on endothelium-derived hyperpolarization (EDH)-KCa2.3/KCa3.1 type relaxation in isolated endothelium-intact
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