S5265
Streptolysin O from Streptococcus pyogenes
lyophilized powder, Protein ~3 % by Lowry, 25,000-50,000 U/vial
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About This Item
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Formulário
lyophilized powder
Nível de qualidade
atividade específica
25,000-50,000 U/vial
peso molecular
native 69 kDa
composição
Protein, ~3% Lowry
condição de armazenamento
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
cor
white
solubilidade
H2O: soluble 1 mg/mL
espectro de atividade do antibiótico
neoplastics
Modo de ação
cell membrane | interferes
temperatura de armazenamento
2-8°C
Informações sobre genes
Streptococcus pyogenes MGAS8232 ... slo(993428)
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Categorias relacionadas
Aplicação
Permeabilizes membranes to permit cellular uptake of large or charged molecules.
Streptolysin O is a toxin secreted by Streptococcus pyogenes and is a prototype member of poreforming bacterial cytolysins. It is used permeabilize cell membranes to permit cellular uptake of large or charged molecules. It is used to study macromolecule delivery. It is a potential anticancer agent and is used to study suicide cancer gene therapy.
Used to create holes (reversible pores) in cholesterol-enriched plasma membranes of eukaryotic cells allowing selective permeabilization with molecules such as proteins (up to 100 kDa) and siRNAs.
Ações bioquímicas/fisiológicas
Streptolysin O possesses a single polypeptide chain with a molecular weight of f62 kDa. Streptolysin O binds to membrane cholesterol and oligomerizes to create a ring structure that consists of 45 to 50 units. The ring structure inserts into the membrane to make a large pore (25 to 30 nm), which DNA, RNA, peptides and proteins may pass. It is thiol-activated. It is inhibited by allicin, an active component of garlic.
Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.
Thiol-activated toxin that permeabilizes animal cell membranes..
Embalagem
25KU
Definição da unidade
One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.
forma física
Lyophilized powder containing Tris buffer salts, sodium azide, PMSF, and EDTA.
Outras notas
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place
Palavra indicadora
Danger
Frases de perigo
Classificações de perigo
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
Código de classe de armazenamento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Mohsen Arzanlou et al.
Journal of medical microbiology, 59(Pt 9), 1044-1049 (2010-06-12)
Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated the effect of allicin and aqueous garlic extracts
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Exosomes are small membrane vesicles secreted by a wide variety of cells. Studies have demonstrated that exosomal miRNAs can influence the biological processes of recipient cells. Therefore, direct imaging and tracking of exosomal miRNAs in living recipient cells are essential
Wan Seok Yang et al.
Molecular cancer therapeutics, 5(6), 1610-1619 (2006-07-05)
We cloned the streptolysin O gene from the Streptococcus pyogenes genome and tested the possibility of using it as an anticancer reagent. Transient transfection of the streptolysin O gene efficiently killed 293T cells after 12 hours of transfection as determined
John Popovich et al.
Frontiers in bioengineering and biotechnology, 8, 527-527 (2020-06-26)
Pore-forming and hemolytic toxins are bacterial cytotoxic proteins required for virulence in many pathogens, including staphylococci and streptococci, and are notably associated with clinical manifestations of disease. Inspired by adsorption properties of naturally occurring aluminosilicates, we engineered inexpensive, laboratory-synthesized, aluminosilicate
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