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S1940

Sigma-Aldrich

Anti-phospho-Src (pTyr418) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Sinônimo(s):

Anti-pp60src(pY418)

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About This Item

Número MDL:
MFCD03455768
Código UNSPSC:
12352203
NACRES:
NA.44

fonte biológica

rabbit

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous glycerol solution

reatividade de espécies

chicken, mouse, human, rat

técnica(s)

western blot: 1:1,000 using human platelets or mouse NIH3T3 cells

nº de adesão UniProt

P12931

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

phosphorylation (pTyr418)

Informações sobre genes

human ... SRC(6714)
mouse ... Src(20779)
rat ... Src(83805)

Descrição geral

Src is a proto-oncogene that regulates neuronal functions, such as nerve cell differentiation. The Src kinase family structurally comprises of SH2, SH3 and kinase domains, as well as a negative regulatory C-terminal tail. Src has also been implicated in functions such as cell growth, development and cell-cell interactions . Anti-phospho-Src p(Tyr418) antibody is specific for human, mouse, rat and chicken Src (60 kDa).

Imunogênio

The sequence is conserved in human, mouse, chicken and frog.
synthetic phosphopeptide derived from the region of src that contains tyrosine 418, based on the sequence of human src.

Aplicação

Anti-phospho-Src p(Tyr418) antibody is suitable for use in western blot (1:1,000 using human platelets or mouse NIH3T3 cells). The product may also be used for immunoprecipitation (1:1000 using HEK293 or HEL cell lysates ).

forma física

Solution in Dulbecco′s phosphate-buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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T J Allen et al.
The Journal of physiology, 508 ( Pt 1), 1-14 (1998-06-06)
1. We examine the actions of a chemical phosphatase, 2,3-butanedione monoxime (BDM), on endogenous and expressed Ca2+ channel currents in Xenopus oocytes. In previous studies on L-type Ca2+ channel currents in cardiomyocytes and dorsal root ganglia, the inhibitory effects of
G Superti-Furga et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 17(4), 321-330 (1995-04-01)
There is increasing evidence to suggest that cytoplasmic tyrosine kinases of the Src family have a pivotal role in the regulation of a number of cellular processes. Members of this family have been implicated in cellular responses to a variety
J R Engen et al.
Cellular and molecular life sciences : CMLS, 65(19), 3058-3073 (2008-06-20)
Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray
C A Ingraham et al.
Molecular and chemical neuropathology, 10(1), 1-14 (1989-02-01)
The proto-oncogene c-src has been implicated in the development and mature function of the nervous system. pp60c-src, the protein product of the c-src gene, is a tyrosine protein kinase that is highly enriched in fetal neural tissue. pp60c-src appears in
Xiaoming Fan et al.
International journal of molecular sciences, 19(7) (2018-07-25)
Non-coding RNAs are important regulators of protein-coding genes. The current study characterized an antisense long non-coding RNA, ATP1A1-AS1, which is located on the opposite strand of the Na/K-ATPase α1 gene. Our results show that four splice variants are expressed in
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