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S1875

Sigma-Aldrich

(−)-Scopolamine hydrobromide trihydrate

≥98% (HPLC), powder

Sinônimo(s):

Hyoscine hydrobromide, Scopine tropate

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About This Item

Fórmula empírica (Notação de Hill):
C17H21NO4 · HBr · 3H2O
Número CAS:
6533-68-2
Peso molecular:
438.31
Beilstein:
6100669
Número MDL:
MFCD00150066
Código UNSPSC:
12352116
ID de substância PubChem:
24277871
NACRES:
NA.77

Nível de qualidade

200

Ensaio

≥98% (HPLC)

forma

powder

atividade óptica

[α]25/D −24 to −26°, c = 5 in H2O(lit.)

cor

white to off-white

pf

195-199 °C (dry matter) (lit.)

solubilidade

H2O: 50 mg/mL

cadeia de caracteres SMILES

O.O.O.Br.CN1[C@@H]2C[C@H](C[C@H]1[C@@H]3O[C@H]23)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.BrH.3H2O/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;;;;/h2-6,11-16,19H,7-9H2,1H3;1H;3*1H2/t11-,12-,13-,14+,15-,16+;;;;/m1..../s1

chave InChI

LACQPOBCQQPVIT-SEYKEWMNSA-N

Informações sobre genes

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Procurando produtos similares? Visita Guia de comparação de produtos

Ações bioquímicas/fisiológicas

Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300 + H310 + H330

Classificações de perigo

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

Sigma-Aldrich

5.05818

Scopolamine Hydrobromide

Anisodamine ≥98% (HPLC)

Sigma-Aldrich

SML0252

Anisodamine

Hyoscine hydrobromide impurity B European Pharmacopoeia (EP) Reference Standard

Y0000448

Hyoscine hydrobromide impurity B

vibrant-m

H1600000

Hyoscyamine sulfate

Min-Hee Pang et al.
Neurobiology of learning and memory, 94(2), 206-213 (2010-08-06)
Although cholinergic mechanisms have been widely implicated in learning and memory processes, few studies have investigated the specific contribution of hippocampal cholinergic transmission during trace fear conditioning, a form of associative learning involving a temporal gap between two stimuli. Microinfusions
Jean-Pascal Morin et al.
Neuroscience letters, 740, 135466-135466 (2020-11-06)
The sense of taste provides information regarding the nutrient content, safety or potential toxicity of an edible. This is accomplished via a combination of innate and learned taste preferences. In conditioned taste aversion (CTA), rats learn to avoid ingesting a
Mehrnoosh Nikpour et al.
ACS chemical neuroscience, 11(17), 2549-2565 (2020-07-08)
Alzheimer's disease (AD) is one of the most common types of neurodegenerative diseases which is accompanied by irreversible neuronal damage, learning difficulties, memory impairments, and cognitive disorders. The cholinergic system is destroyed during AD pathogenesis, leading to the major symptoms
Silviya Abarova et al.
Biochimica et biophysica acta, 1863(11), 2934-2941 (2017-08-06)
Differential scanning calorimetry was applied to evaluate the efficacy of preventive treatments with biologically active compounds of plant origin against neurodegenerative disorder in mice. As we reported recently, large differences exist between the heat capacity profiles of water-soluble brain proteome
Sasha Devore et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11244-11260 (2014-08-22)
The olfactory bulb (OB) and piriform cortex receive dense cholinergic projections from the basal forebrain. Cholinergic modulation within the piriform cortex has long been proposed to serve important functions in olfactory learning and memory. We here investigate how olfactory discrimination
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