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S0693

Sigma-Aldrich

SB 204741

>98% (HPLC)

Sinônimo(s):

N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea

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About This Item

Fórmula empírica (Notação de Hill):
C14H14N4OS
Número CAS:
152239-46-8
Peso molecular:
286.35
Número MDL:
MFCD00923644
Código UNSPSC:
12352200
ID de substância PubChem:
24278321
NACRES:
NA.77

Nível de qualidade

100

Ensaio

>98% (HPLC)

forma

solid

cor

off-white to tan

solubilidade

DMSO: soluble >20 mg/mL

originador

GlaxoSmithKline

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1

InChI

1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)

chave InChI

USFUFHFQWXDVMH-UHFFFAOYSA-N

Informações sobre genes

human ... DRD2(1813) , DRD3(1814) , DRD5(1816) , HTR1E(3354) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
rat ... Adra1a(29412) , Gabra2(29706) , Htr1a(24473) , Htr2b(29581) , Htr3a(79246)

Aplicação

SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:
  • to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish
  • to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral studies in mice
  • to test its effect in reducing scratching behavior evoked by sertraline in mice

Ações bioquímicas/fisiológicas

SB 204741 reduces the synaptic facilitation induced by the low dose of buprenorphine in spinal C-fiber synapses.
5-HT2B serotonin receptor antagonist.

Características e benefícios

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações legais

Sold for research purposes under agreement from Glaxo­Smith­Kline

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Xiaowei Li et al.
Frontiers in psychiatry, 9, 734-734 (2019-01-23)
The long-lasting loss of sleep is a generally acknowledged risk factor for the occurrence of major depressive disorder (MDD), whereas sleep abnormalities being a key clinic symptom of the MDD. In our previous work, we demonstrated that the sleep deprivation
Ercan Ozdemir et al.
Bioelectromagnetics, 40(5), 319-330 (2019-06-04)
Much evidence demonstrates the antinociceptive effect of magnetic fields (MFs). However, the analgesic action mechanism of the electromagnetic field (EMF) is not exactly understood. The aim of the present study was to investigate the effects of 5-HT1 and 5-HT2 receptor
Qiqi Yang et al.
Cellular and molecular gastroenterology and hepatology, 3(3), 484-499 (2017-05-04)
Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than in women. Although sex hormones are believed to play a critical role in this disparity, the possible contribution of other factors largely is unknown. We aimed to investigate the
Annika Gocht et al.
Transplant immunology, 49, 43-53 (2018-04-13)
Cardiac allograft vasculopathy (CAV) is the main obstacle for long-term survival after heart transplantation. Alloimmune mediated chronic vascular rejection results in several mechanisms like platelet activation, immigration of inflammatory cells through the endothelial layer and proliferation and migration of smooth
Qiqi Yang et al.
Scientific reports, 8(1), 8495-8495 (2018-06-02)
Activation of hepatic stellate cells (HSC) plays a crucial role in the liver disease progression from liver fibrosis/cirrhosis to cancer. Here, we found a rapid change of microenvironment after kras V12 -induction in zebrafish liver with progressively increased stromal cell
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