R3375

Retinyl palmitate

Type IV, ~1,800,000 USP units/g, oil

• Sinônimo(s): Vitamin A palmitate, all−trans−Retinol palmitate
• Fórmula empírica (Notação de Hill): C₃₆H₆₀O₂
• Número CAS: 79-81-2
• Peso molecular: 524.86
• Beilstein: 1917366
• Número CE: 201-228-5
• Número MDL: MFCD00019414
• Código UNSPSC: 12352205
• ID de substância PubChem: 24899361
• NACRES: NA.79

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 100
• tipo: Type IV
• Ensaio: ≥90% (HPLC)
• forma: oil
• atividade específica: ~1,800,000 USP units/g
• cor: yellow to orange
• pf: 26 °C
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1
• InChI: 1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
• chave InChI: VYGQUTWHTHXGQB-FFHKNEKCSA-N

Descrição

Descrição geral

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A, respectively. The retinoids comprise a cyclohexenyl ring with a 20-carbon with double bonds in cis and trans configuration. Retinyl palmitate is a major storage form of vitamin A. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Aplicação

Retinyl palmitate has been used as:

• a retinoid derivative to modulate expression of connexin Cx26 and Cx30 in the cochlea
• a standard in high performance liquid chromatography(HPLC)
• as a retinoid substrate in the isomerase assay of eyecup protein homogenates

Ações bioquímicas/fisiológicas

Retinoids are ligands to nuclear receptors and have antioxidant functionality. Retinyl palmitate is widely used in pharmaceutical and cosmetic applications. In sunscreen, it protects from UVB-induced DNA damage and apoptosis. Retinyl palmitate is used to treat photoaging in skincare cosmetics. Retinyl palmitate is an effective chemopreventive agent to treat lung cancer. It also regulates various biological processes including cell differentiation and proliferation.

Review: Vitamin A metabolism.

Embalagem

Sealed ampule.

forma física

Oil at room temperature

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360D,H412
• Declarações de precaução: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Aquatic Chronic 3 - Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): No data available
• Ponto de fulgor (°C): No data available
• Equipamento de proteção individual: Eyeshields, Gloves, type ABEK (EN14387) respirator filter