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PZ0117

Sigma-Aldrich

PF-573228

≥95% (HPLC)

Sinônimo(s):

6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one, PF-228

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About This Item

Fórmula empírica (Notação de Hill):
C22H20F3N5O3S
Número CAS:
869288-64-2
Peso molecular:
491.49
Número MDL:
MFCD11519967
Código UNSPSC:
12352200
ID de substância PubChem:
329823709
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥95% (HPLC)

Formulário

powder

cor

white to off-white

solubilidade

DMSO: ≥20 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1

InChI

1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)

chave InChI

HESLKTSGTIBHJU-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
103M4735V
060M4725V
042M4744V
060M4625

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Sigma-Aldrich

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Wortmannin

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Sigma-Aldrich

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Hydrazine monohydrate

Meio RPMI-1640 With L-glutamine and sodium bicarbonate, liquid, sterile-filtered, suitable for cell culture

Sigma-Aldrich

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Meio RPMI-1640

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Aim: To study the carcinogenetic mechanism of HOXB7 in gastric cancer (GC) remains. Methods: Two human GC cell lines - SGC7901 and SNU1 - were used for this study. SGC7901 cells were transfected with siRNA-HOXB7 (siHOXB7) to knock down HOXB7
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Small cell lung cancer (SCLC) has a poor prognosis. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase regulating cell proliferation, survival, migration, and invasion, which is overexpressed and/or activated in several cancers, including SCLC. We wanted to determine whether
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