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Key Documents

PRS4809

Sigma-Aldrich

Anti-S1P1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Anti-ECGF1, Anti-EDG1, Anti-S1PR1, Anti-Sphingosine-1-phosphate receptor 1

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About This Item

Número MDL:
MFCD02264095
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

predicted mol wt 42 kDa

reatividade de espécies

human, mouse, rat

técnica(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

nº de adesão UniProt

P21453

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... S1PR1(1901)

Descrição geral

S1P1 (sphingosine-1-phosphate receptor 1) is one of the transmembrane G protein coupled receptor. It is a member of the endothelial differentiation gene (EDG) family of receptors, hence it is also known as endothelial differentiation gene (EDG-1). It is located on chromosome 1p21.

Imunogênio

a 14 amino acid peptide near the carboxy-terminus of the human S1P1.

Ações bioquímicas/fisiológicas

S1P1 (sphingosine-1-phosphate receptor 1) acts as an anti-apoptotic/pro-proliferative protein in AML (acute myeloid leukemia) cells. It participates in angiogenesis and lymphangiogenesis. It is considered as a pro-tumorigenic receptor, as it induces migration of cancer cell and invasion along with tumor neovascularization.

Ligação

The action of this antibody can be blocked using blocking peptide SBP4809.

forma física

Solution in phosphate buffered saline containing 0.02% sodium azide

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sphingosine-1-phosph ate receptor 2
Adada M,et al.
FEBS Journal (2013)
S1PR1 mediates anti?apoptotic/pro?proliferative processes in human acute myeloid leukemia cells
Xu XQ, et al.
Molecular Medicine Reports, 14(4), 3369-3375 (2016)
Qi Lin et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 9743-9750 (2014-06-29)
There are currently no accurate predictive markers of metachronous liver metastasis from colorectal cancer. Recent studies demonstrated that the expression patterns of sphingosine-1-phosphate receptor 1 (S1PR1) are altered in several tumors, but in colorectal cancer, the patterns remain unknown. Our
Babita Rahar et al.
High altitude medicine & biology, 20(1), 78-88 (2019-03-21)
High altitude exposure alters biochemical, metabolic, and physiological features of heart and skeletal muscles, and hence has pathological consequences in these tissues. Central to these hypoxia-associated biochemical/metabolic shuffling are energy deficit accumulation of free radicals and ensuing oxidative damage in

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