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Key Documents

P5660

Sigma-Aldrich

3-sn-Phosphatidyl-L-serine sodium salt from bovine brain

≥95% (TLC)

Sinônimo(s):

1,2-Diacyl-sn-glycero-3-phospho-L-serine, L-α-Phosphatidyl-L-serine sodium salt

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About This Item

Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77

Nível de qualidade

Ensaio

≥95% (TLC)

forma

powder

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Na+].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C([O-])=O)OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/C42H82NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/t38-,39+;/m1./s1

chave InChI

SJRBMGBLPUBGJL-MBAWARMDSA-M

Descrição geral

Phosphatidylserine is an anionic phospholipid, which is found on the plasma membrane. Exposure of phosphatidylserine on the surface of plasma membrane stimulates the removal of apoptotic and red blood cells. It regulates the production of thrombin and maintains hemostasis.

Aplicação

3-sn-Phosphatidyl-L-serine sodium salt from bovine brain has been used as a glycosylphosphatidylinositol (GPI)-anchor control.

Ações bioquímicas/fisiológicas

A slowly metabolized structural phospholipid found mainly in gray matter.

Atenção

Solutions exposed to room temperature will decompose about 0.5% per day.

Nota de preparo

Washed with EDTA and converted to a sodium salt.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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The role of phosphatidylserine in recognition and removal of erythrocytes.
Kuypers FD
Cellular and molecular biology (Noisy-le-Grand, France), 50(2), 147-158 (2004)
Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression
Fadeel B, et al.
Biochemical and Biophysical Research Communications, 266(2), 504-511 (1999)
TIMP-1-GPI in combination with hyperthermic treatment of melanoma increases sensitivity to FAS-mediated apoptosis
Djafarzadeh R, et al.
Cancer Immunology, Immunotherapy, 58(3), 361-361 (2009)
Exposure of platelet membrane phosphatidylserine regulates blood coagulation
Lentz BR
Progress in Lipid Research, 42(5), 423-438 (2003)
Julien Perino et al.
Antiviral research, 89(1), 89-97 (2010-11-26)
Vaccinia virus (VACV) was used as a surrogate of Variola virus (genus Orthopoxvirus), the causative agent of smallpox, to study orthopoxvirus infection via the respiratory airway. Lung surfactant, a physiological barrier to infection encountered by the virus, is predominantly composed

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