P4543

Valproic acid sodium salt

98%

• Sinônimo(s): 2-propylpentanoic acid sodium, Sodium 2-propylpentanoate, Sodium valproate
• Fórmula empírica (Notação de Hill): C₈H₁₅NaO₂
• Número CAS: 1069-66-5
• Peso molecular: 166.19
• Número CE: 213-961-8
• Número MDL: MFCD00078604
• Código UNSPSC: 12352106
• eCl@ss: 42020819
• ID de substância PubChem: 24277744
• NACRES: NA.77

Propriedades

• Ensaio: 98%
• Formulário: powder
• solubilidade: H₂O: 50 mg/mL
• originador: Abbott
• cadeia de caracteres SMILES: [Na+].CCCC(CCC)C([O-])=O
• InChI: 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
• chave InChI: AEQFSUDEHCCHBT-UHFFFAOYSA-M
• Informações sobre genes: human ... ALDH5A1(7915)

Descrição

Descrição geral

The antiepileptic effects of Valproic acid (VPA) are achieved by reducing high-frequency neuronal firing through the blockage of voltage-gated sodium, potassium, and calcium channels. This medication affects the biochemical occurrence of aura and impacts pain perception by modulating GABA or glutamate-mediated neurotransmission. Additionally, VPA influences signaling systems such as the Wnt/beta-catenin and ERK pathways, interfering with inositol and arachidonate metabolism. Furthermore, VPA is crucial in expressing multiple genes involved in cell survival, transcription regulation, ion homeostasis, signaltransduction, and cytoskeletal modifications. Both immediate biochemical effects and long-term genomic influences explain the underlying effect of VPA in treating various conditions.



Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.

Aplicação

Valproic acid sodium salt has been used:

• in resazurin viability assay
• to systematically study its effects of clinical doses on brain volume and offspring behavior
• to study its effect on atherosclerotic lesion size
• in genetic expression studies in mice

Ações bioquímicas/fisiológicas

Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H361d
• Declarações de precaução: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classificações de perigo: Acute Tox. 4 Oral - Repr. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves