About This Item
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Nome do produto
Protamine from salmon, Grade IV, Histone, free(Millon test)
fonte biológica
fish (salmon)
Nível de qualidade
tipo
Grade IV
Formulário
solid
Impurezas
Histone, free (Millon test)
solubilidade
H2O: soluble, clear to slightly hazy, colorless to faintly yellow
temperatura de armazenamento
−20°C
Descrição geral
Protamines are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine. It is found to be localized to the sperm head.
Aplicação
Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin. It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.
Ações bioquímicas/fisiológicas
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamines are found to displace histones in DNA during spermatogenesis in animals and plants. Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin
Petersen LC, et al.
British Journal of Haematology, 152(1), 99-107 (2011)
Adsorption characteristics of various proteins on a metal surface in the presence of an external electric potential
Htwe EE, et al.
Colloids and Surfaces, B: Biointerfaces, 262-268 (2018)
Protamine and protamine reactions
Park Kyung W
International Anesthesiology Clinics, 42(3), 135-145 (2004)
Vanesa Lafarga et al.
The EMBO journal, 40(13), e103311-e103311 (2021-05-13)
Due to their capability to transport chemicals or proteins into target cells, cell-penetrating peptides (CPPs) are being developed as therapy delivery tools. However, and despite their interesting properties, arginine-rich CPPs often show toxicity for reasons that remain poorly understood. Using
The protamine family of sperm nuclear proteins
Balhorn Rod
Genome Biology, 8(9), 227-227 (2007)
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