O7635

Anti-Osteopontin antibody produced in goat

affinity isolated antibody, lyophilized powder

• Sinônimo(s): Anti-OPN
• Número MDL: MFCD02263865
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: goat
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: lyophilized powder
• reatividade de espécies: mouse
• técnica(s): capture ELISA: 0.2-0.8 μg/mL; immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections; neutralization: 1-3 μg/mL; western blot: 0.1-0.2 μg/mL
• nº de adesão UniProt: P10923
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: mouse ... Spp1(20750)

Descrição

Descrição geral

The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.

Imunogênio

purified recombinant mouse osteopontin expressed in NSO cells.

Ações bioquímicas/fisiológicas

Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.

forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Nota de análise

Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable