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N4773

Sigma-Aldrich

Neuron-specific enolase from human brain

≥95% (SDS-PAGE), buffered aqueous solution

Sinônimo(s):

2-Phospho-D-glycerate hydro-lyase, Enolase, Neuron-specific from human brain, NSE, Thermolabile antigen A

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About This Item

Número da licença da enzima:
4.2.1.11 (BRENDA, IUBMB)
Número MDL:
MFCD00081785
Código UNSPSC:
12352204
NACRES:
NA.54

fonte biológica

human brain

Nível de qualidade

200

Ensaio

≥95% (SDS-PAGE)

Formulário

buffered aqueous solution

atividade específica

≥10 units/mg protein

nº de adesão UniProt

P09104

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... ENO2(2026)

Descrição geral

Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue.

Aplicação

Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. It has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features.

Ações bioquímicas/fisiológicas

Neuron-specific enolase (NSE) is expressed in all neuronal cell types, and its expression marks the acquisition of synaptic function. Following acute neuronal injury, NSE levels are increased in neuronal cell bodies. Increased levels of NSE in serum and cerebrospinal fluid have been used as markers for injury and neuronal cell death. Tumors derived from many cell types, including most neuronal and neuroendocrine tumors, express NSE.
Neuron-specific enolase promotes survival of neurons and can provide neuroprotective effects by binding to neurons in a calcium-dependent manner.

Definição da unidade

One unit causes the formation of 1.0 μmole of phospho(enol)pyruvate per minute at pH 6.8 at 25 °C

forma física

Solution in 100 mM Tris-HCl, 5 mM MgSO4, 250 mM KCl, pH 5.0-5.2

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
SLCK3880
SLCF2732
SLBX5257
SLBP5891V
SLBM3136V

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Transplantation of human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia
Li, F., et al.
Molecular Medicine, 6, 625-630 (2012)
Neuron-specific enolase is produced by neuroendocrine tumours
Tapia, F., et al.
Lancet, 317, 808-811 (1981)
T Hattori et al.
Neuroscience research, 21(3), 191-198 (1995-01-01)
We previously reported that the gamma gamma-isozyme of enolase, NSE), one of the glycolytic enzymes, promoted the survival of embryonic rat neocortical neurons in culture, but alpha alpha-isozyme (non-neuronal enolase) had no effect. In the present study, the neurotrophic effects
Jo-Heon Kim et al.
Pathology international, 61(12), 762-767 (2011-12-01)
Sinonasal teratocarcinosarcoma (SNTCS) is a very rare tumor developed in the nasal cavity and paranasal sinuses. The rhabdoid phenotype represents an aggressive biological behavior, but the rhabdoid feature has hitherto not been reported in cases of SNTCS. A 46-year-old man
O A Iuneman et al.
Arkhiv patologii, 74(5), 23-26 (2013-01-25)
The paper gives the data of studying the cells belonging to neuroblast progeny in embryonic origin. Differentiation in these cells was studied by immunohistochemical assay using a number of neuronal markers. Expression of S-100, NCAM, and neuron-specific enolase was revealed
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