N1413

NSCI

≥97% (HPLC), solid

• Sinônimo(s): 1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione
• Fórmula empírica (Notação de Hill): C₂₆H₂₅N₃O₆S
• Número CAS: 872254-32-5
• Peso molecular: 507.56
• Código UNSPSC: 12352200
• ID de substância PubChem: 24897488
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• Formulário: solid
• solubilidade: DMSO: >10 mg/mL; H₂O: insoluble
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N4CCC[C@H]4COc5cccnc5)cc1
• InChI: 1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1
• chave InChI: XDHJBIYJRNFDKS-IBGZPJMESA-N
• Informações sobre genes: human ... CASP1(834) , CASP3(836) , CASP6(839) , CASP7(840) , SUMO1(7341)

Descrição

Aplicação

NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4⁺) and cluster of differentiation 8 (CD8⁺) T cells from pleural effusions, mononuclear cells (PEMCs).

Ações bioquímicas/fisiológicas

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.

Características e benefícios

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable