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MAK314

Sigma-Aldrich

Sialic Acid Assay Kit

sufficient for 100 colorimetric or fluorometric tests

Sinônimo(s):

Sialic Acid (NANA) Assay Kit

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About This Item

Código UNSPSC:
12161503
NACRES:
NA.84

uso

sufficient for 100 colorimetric or fluorometric tests

método de detecção

colorimetric
fluorometric

doença(s) relevante(s)

cancer; cardiovascular diseases; hematological disorder

temperatura de armazenamento

−20°C

Categorias relacionadas

Descrição geral

Sialic Acid is a general name for nine carbon acidic sugars with N- or O-substituted derivatives. The most common member of these sugars is N-acetylneuraminic acid (NANA). They are associated with carbohydrates and are localized on cell membranes. Sialic acid is widely distributed throughout mammalian tissues and fluids including serum. Sialylated oligosaccharides have been shown to exhibit antiviral properties and are also known to influence blood coagulation and cholesterol levels. The sialic acid level in body fluids is also an important marker for diagnosing cancer.

Aplicação


  • Evaluation of serum total sialic acid in moderate COVID-19 patients with and without gastrointestinal tract manifestations.: The study measures serum sialic acid levels in COVID-19 patients to understand the disease′s impact on the gastrointestinal tract (Haroun et al., 2022).

Adequação

Suitable for the quantitative determination of free and total sialic acid (NANA) and evaluation of drug effects on sialic acid in serum, plasma, saliva, milk etc.

Princípio

This sialic acid assay uses an improved Warren method, in which sialic acid is oxidized to formylpyruvic acid. This reacts with thiobarbituric acid to form a pink colored product. The colorimetric (549nm)/fluorimetric (λex = 555nm/λem = 585nm) product is directly proportional to sialic acid concentration in the sample.

Palavra indicadora

Danger

Frases de perigo

H290,H314,H335,H411

Classificações de perigo

Aquatic Chronic 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Sialic acids: fascinating sugars in higher animals and man.
Schauer R.
Zoology (Jena, Germany), 107(1), 49-64 (2004)
Sialic Acids
Varki A, et al.
Essentials Of Glycobiology. 2nd Edition. (2009)
Salivary total sialic acid levels increase in breast cancer patients: a preliminary study.
Ozturk L K, et al.
Medicinal Chemistry, 7(5), 443-447 (2011)
Alice J Stelfox et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(43), 21514-21520 (2019-10-09)
The bat-borne paramyxovirus, Sosuga virus (SosV), is one of many paramyxoviruses recently identified and classified within the newly established genus Pararubulavirus, family Paramyxoviridae The envelope surface of SosV presents a receptor-binding protein (RBP), SosV-RBP, which facilitates host-cell attachment and entry.

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