M8816

Microsomes from Liver, Pooled

from Monkey(Cynomolgus spp.), male

• Sinônimo(s): lab equipment accessory
• Código UNSPSC: 12161501
• NACRES: NB.35

Propriedades

• fonte biológica: Monkey (Cynomolgus spp.)
• Formulário: liquid
• atividade específica: ≥5000 units/mg protein
• embalagem: vial of ~10 mg
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C

Descrição

Aplicação

Microsomes from Liver, Pooled has been used to measure the in vitro stabilities of the prodrugs. It has also been used in microsomal incubation to generate BTX-3 metabolites to serve as references for liquid chromatography with tandem mass spectrometry (LC-MS/MS) analyses of urine.

Ações bioquímicas/fisiológicas

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Microsomal cytochrome P450 proteins can catalyze the transfer of a single oxygen atom to endogenous and exogenous compounds, like steroids and phenobarbital, meant for excretion and detoxification.

Definição da unidade

One unit will produce 1.0 picomole of 6 beta-hydroxytestosterone per minute at pH 7.4 at 37 deg C.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable