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Key Documents

Outros documentos

M6690

Sigma-Aldrich

MDL 28170

≥90% (TLC)

Sinônimo(s):

Calpain Inhibitor III

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About This Item

Fórmula empírica (Notação de Hill):
C22H26N2O4
Número CAS:
88191-84-8
Peso molecular:
382.45
Número MDL:
MFCD00798796
Código UNSPSC:
12352200
ID de substância PubChem:
24278565
NACRES:
NA.77

Nível de qualidade

200

Ensaio

≥90% (TLC)

composição

Peptide Content, >90%

solubilidade

DMSO: 26 mg/mL
H2O: insoluble
methanol: soluble

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C

InChI

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1

chave InChI

NGBKFLTYGSREKK-ANYOKISRSA-N

Informações sobre genes

human ... CAPN1(823) , CAPN2(824)

Amino Acid Sequence

Z-Val-Phe-al

Aplicação

MDL 28170 has been used as a calpain inhibitor:
  • to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest
  • to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle
  • to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain

Ações bioquímicas/fisiológicas

MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats. It also shows anti-inflammatory and anti-neurodegenerative properties. MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.
MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Memory consolidation has been suggested to be protein synthesis dependent. Previous data indicate that BDNF-induced dendritic protein synthesis is a key event in memory formation through activation of the mammalian target of rapamycin (mTOR) pathway. BDNF also activates calpain, a
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Low-frequency depression (LFD) of transmitter release occurs at phasic synapses with stimulation at 0.2 Hz in both isolated crayfish (Procambarus clarkii) neuromuscular junction (NMJ) preparations and in intact animals. LFD is regulated by presynaptic activity of the Ca(2+)-dependent phosphatase calcineurin
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Cerebral ischemia-reperfusion injury (CIRI) is the leading cause of poor neurological prognosis after cardiopulmonary resuscitation (CPR). We previously reported that the extracellular signal-regulated kinase (ERK) activation mediates CIRI. Here, we explored the potential ERK/calpain-2 pathway role in CIRI using a
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Biochemical and biophysical research communications, 423(1), 1-5 (2012-05-12)
Matrix metalloproteinase (MMP)-2 is a zinc-dependent endopeptidase which, alongside its known extracellular actions, plays fundamental roles in oxidative stress-induced injury to the heart. Intracellular cleavage targets of MMP-2 selectively mediating this injury include the sarcomeric proteins troponin I, myosin light
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