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M217

Monoclonal Anti-Nicotinic Acetylcholine Receptor (α₁, α₃, α₅ Subunits) antibody produced in rat

Name: Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat
Brand: SIGMA

clone mAb 35, purified immunoglobulin, buffered aqueous solution

Sinônimo(s):

Anti-ACHR

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About This Item

Número MDL:

MFCD00677279

Código UNSPSC:

12352203

NACRES:

NA.43

fonte biológica

rat

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

mAb 35, monoclonal

forma

buffered aqueous solution

reatividade de espécies

human, chicken, eel

não deve reagir com

Xenopus

técnica(s)

immunohistochemistry (frozen sections): 1:3,000

Isotipo

IgG1

nº de adesão UniProt

CHRNA1

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CHRNA1(1134) , CHRNA3(1136) , CHRNA5(1138)

Especificidade

Binds to the main immunogenic region on the extracellular surface of the α₁ subunit of muscle AChR′s and to homologous regions on α₃ and α₅ subunits of neuronal AChR′s. The epitope is located on the extracellular surface of the α₁ subunit of the muscle nicotinic acetylcholine receptor. The antibody binds to denatured chick α₅ AChR, but does not bind well to denatured α₃, α₄, α₇, α_8, and β₂. It may also bind β₃ due to homology of main immunogenic region. May be used to localize and detect the α₁, α₃ and α₅ subunits of the nicotinic acetylcholine receptor (AChR).

Imunogênio

nicotinic acetylcholine receptor from the electric eel Electrophorus.

forma física

Solution in 20 mM Na₃PO₄, pH 7.2, containing 150 mM NaCl and 0.05 % sodium azide.

Informações legais

Sold with permission of the Salk Institute

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Purification and characterization of a nicotinic acetylcholine receptor from chick brain.

P J Whiting et al.

Biochemistry, 25(8), 2082-2093 (1986-04-22)

Immunohistochemical studies have previously shown that both the chick brain and chick ciliary ganglion neurons contain a component which shares antigenic determinants with the main immunogenic region of the nicotinic acetylcholine receptor from electric organ and skeletal muscle. Here we

Characterization and localization of adrenal nicotinic acetylcholine receptors: evidence that mAb35-nicotinic receptors are the principal receptors mediating adrenal catecholamine secretion.

H Gu et al.

Journal of neurochemistry, 66(4), 1454-1461 (1996-04-01)

Adrenal chromaffin cells contain at least two subtypes of nicotinic acetylcholine receptors (nAChRs). These studies were designed to identify and characterize the subtype of nAChR mediating adrenal catecholamine release using the monoclonal antibody mAb35, which recognizes the alpha-subunit of muscle

A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses.

Jee-Young Park et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10211-10218 (2014-08-01)

Mutations in AChR subunits, expressed as pentamers in neuromuscular junctions (NMJs), cause various types of congenital myasthenic syndromes. In AChR pentamers, the adult ε subunit gradually replaces the embryonic γ subunit as the animal develops. Because of this switch in

The alpha 5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain.

W G Conroy et al.

Neuron, 9(4), 679-691 (1992-10-01)

The acetylcholine receptor (AChR) alpha 5 gene has been classified as a member of the AChR gene family based on sequence homology. Expression studies, however, have yet to identify a function for the alpha 5 gene product or even to

Determination of amino acids critical to the main immunogenic region of intact acetylcholine receptors by in vitro mutagenesis.

M S Saedi et al.

FEBS letters, 267(1), 55-59 (1990-07-02)

The main immunogenic region (MIR) of the acetylcholine receptor (AChR) is the target for the majority of high-affinity autoantibodies produced in myasthenia gravis patients. Some monoclonal antibodies (mAbs) to the MIR bind specifically, but with low affinity, to synthetic AChR

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