L2792
LCK, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinônimo(s):
YT16, p56lck, pp58lck
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About This Item
Produtos recomendados
recombinante
expressed in baculovirus infected Sf9 cells
Nível de qualidade
linha de produto
PRECISIO® Kinase
Ensaio
≥70% (SDS-PAGE)
Formulário
buffered aqueous glycerol solution
atividade específica
180-244 nmol/min·mg
peso molecular
~84 kDa
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... LCK(3932)
Ações bioquímicas/fisiológicas
LCK (proto-oncogene) belongs to the Src family of kinase and is mainly expressed in T cells. It is important for T cell development and homeostasis. LCK is upregulated in acute and chronic leukemias, colorectal and prostate cancers.
Tyrosine kinase that activates T-lymphocytes.
forma física
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Informações legais
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
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Nº do produto
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Preços
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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S Fischer et al.
Biochemical and biophysical research communications, 143(3), 819-826 (1987-03-30)
High levels of tyrosine kinase activity have been detected in the murine lymphoma LSTRA (p56). The functional domains of this kinase have been studied by the use of antibodies generated against peptides from the amino terminal region and from the
A Veillette et al.
Oncogene research, 1(4), 357-374 (1987-09-01)
The tyrosine kinase p56lck is felt to be expressed solely in cells and tissues of lymphoid lineage. We have observed in the particulate fractions of colon carcinoma cells the presence of a 56 kilodalton (kD) alkali resistant phosphoprotein containing phosphotyrosine.
Shahrooz Vahedi et al.
Oncology reports, 34(1), 43-50 (2015-05-23)
Overexpression and hyperactivation of lymphocyte-specific protein tyrosine kinase (Lck) have been associated with leukemia development. We previously showed that, other than its known function as a cytoplasmic signal transducer, Lck also acts as a nuclear transcription factor in mouse leukemic
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