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I8529

Sigma-Aldrich

Insulin-like Growth Factor Binding Protein-5 human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sinônimo(s):

IGFBP-5

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About This Item

Número MDL:
MFCD03457235
Código UNSPSC:
51111800
NACRES:
NA.32

fonte biológica

human

Nível de qualidade

100

recombinante

expressed in NSO cells

Ensaio

>90% (SDS-PAGE)

forma

lyophilized powder

potência

0.5-1.5 mg per mL ED50

peso molecular

34 kDa by SDS-PAGE (reducing)
calculated mol wt ~28 kDa

embalagem

pkg of 25 μg

Impurezas

endotoxin, tested

nº de adesão UniProt

P24593

temperatura de armazenamento

−20°C

Informações sobre genes

human ... IGFBP5(3488)

Descrição geral

The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.

Ações bioquímicas/fisiológicas

IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression.
IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.

forma física

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

Nota de análise

The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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V Hwa et al.
Endocrine reviews, 20(6), 761-787 (1999-12-22)
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other potential IGFBPs was left open. The discovery of
Baxter, R.C.
American Journal of Physiology. Endocrinology and Metabolism, 278 (2000)
Yunyun Su et al.
PloS one, 10(6), e0130546-e0130546 (2015-06-24)
Insulin-like growth factor binding protein (IGFBP)-5 levels are increased in systemic sclerosis (SSc) skin and lung. We previously reported that IGFBP-5 is a pro-fibrotic factor that induces extracellular matrix (ECM) production and deposition. Since IGFBP-5 contains a nuclear localization signal
Maya Ghoussaini et al.
Nature communications, 4, 4999-4999 (2014-09-24)
GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes
Mark E Reeves et al.
PloS one, 9(7), e101679-e101679 (2014-07-10)
RASSF1C is a major isoform of the RASSF1 gene, and is emerging as an oncogene. This is in contradistinction to the RASSF1A isoform, which is an established tumor suppressor. We have previously shown that RASSF1C promotes lung cancer cell proliferation

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