I7908

IL-2 human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture

• Sinônimo(s): IL-2, Interleukin-2, T-cell growth factor
• Número MDL: MFCD00165721
• Código UNSPSC: 12352202
• NACRES: NA.75

Propriedades

• Nome do produto: Interleukin-2 human, recombinant, expressed in Pichia pastoris, suitable for cell culture
• fonte biológica: human
• Nível de qualidade: 200
• recombinante: expressed in Pichia pastoris
• Ensaio: ≥98% (SDS-PAGE and HPLC)
• Formulário: lyophilized powder
• peso molecular: predicted mol wt ~15 kDa
• embalagem: pkg of 10KU
• técnica(s): cell culture | mammalian: suitable
• Impurezas: endotoxin, tested
• nº de adesão UniProt: P60568
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... IL2(3558)

Descrição

Aplicação

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Ações bioquímicas/fisiológicas

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

forma física

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Nota de análise

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)