I0523

IL-2 mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Sinônimo(s): mIL-2, IL-2, T-cell growth factor
• Número MDL: MFCD00164816
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• product name: Interleukin-2 from mouse, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• fonte biológica: mouse
• Nível de qualidade: 200
• recombinante: expressed in E. coli
• Ensaio: ≥97% (SDS-PAGE)
• forma: lyophilized powder
• potência: ≤0.2 ng/mL ED₅₀
• qualidade: endotoxin tested
• peso molecular: 17.2 kDa
• embalagem: pkg of 5X20 μg; pkg of 20 μg
• técnica(s): cell culture | mammalian: suitable
• Impurezas: ≤1.000 EU/μg
• cor: white
• nº de adesão UniProt: P04351
• temperatura de armazenamento: −20°C
• Informações sobre genes: mouse ... Il2(16183)

Descrição

Descrição geral

IL-2 (interleukin-2) codes for a pro-inflammatory cytokine. IL-2 is mostly expressed in T helper cells.

Aplicação

Interleukin-2 from mouse has been used to induce sepsis in rat model. It has also been used in dendritic epidermal T cell culture.

Ações bioquímicas/fisiológicas

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long-term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of natural killer cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. IL-2 expression is known to reduce with age and results in influenza infection, neoplasms and lethal autoimmunity. IL-2 participates in T cell proliferation and differentiation and controls the homeostasis of T cell. As a part of immune response, IL-2 stimulates the action of T helper cell 1 and 2 along with endothelial white blood cells of skeletal muscles. IL-2 regulation is controlled by c-rel protein. IL-2 is a neurotrophic molecule and has special functions in cortical, hippocampal, septal, cerebellar and retinal neurons.

forma física

Lyophilized from a 0.2 μm filtered solution in 10 mM sodium citrate, pH 4.0.

Nota de análise

Activity was determined by dose-dependent stimulation of murine CTLL-2 cells. ED₅₀ : ≤ 0.2 ng/ml (corresponds to a specific activity of 5 × 10⁶ units/mg)

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)