I4028

Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

clone 70625.111, purified immunoglobulin, lyophilized powder

• Sinônimo(s): Anti-IL-18 Receptor
• Número MDL: MFCD02096767
• Código UNSPSC: 51111800
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 70625.111, monoclonal
• Formulário: lyophilized powder
• reatividade de espécies: human
• técnica(s): flow cytometry: suitable (2.5μg/SUP>10^{6 cell)}; immunocytochemistry: 8-25 μg/mL; immunohistochemistry: 8-25 μg/mL
• Isotipo: IgG1
• nº de adesão UniProt: Q13478
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... IL18R1(8809)

Descrição

Descrição geral

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Imunogênio

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Ações bioquímicas/fisiológicas

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Nota de preparo

Purified using protein G.

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable