Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

View All Documentation

H5257

Sigma-Aldrich

Hispidin

solid, ≥98% (HPLC)

Sinônimo(s):

6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C13H10O5
Número CAS:
555-55-5
Peso molecular:
246.22
Número MDL:
MFCD01866972
Código UNSPSC:
12352200
ID de substância PubChem:
24278468
NACRES:
NA.77

fonte biológica

synthetic (organic)

Ensaio

≥98% (HPLC)

forma

solid

condição de armazenamento

protect from light

cor

yellow to brown

pf

237.5-238.5  °C

solubilidade

DMSO: >10 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O

InChI

1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+

chave InChI

SGJNQVTUYXCBKH-HNQUOIGGSA-N

Informações sobre genes

human ... PRKACB(5567) , PRKAR2B(5577) , PRKCB(5579)

Descrição geral

Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.

Ações bioquímicas/fisiológicas

Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
Potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

No data available

Ponto de fulgor (°C)

No data available

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Wei Chen et al.
Chemico-biological interactions, 199(3), 137-142 (2012-07-24)
Oxidative stress plays an important role in the progression of many chronic diseases including cardiovascular diseases, diabetes, cancer and neurodegenerative disorders. One such mediator of oxidative stress is peroxynitrite, which is highly toxic to cultured neurons and astrocytes, and has
Guan-Jhong Huang et al.
Journal of agricultural and food chemistry, 59(10), 5702-5706 (2011-04-02)
The inhibitory activity from the isolated component of the fruiting body Phellinus merrillii (PM) was evaluated against α-glucosidase and lens aldose reductase from Sprague-Dawley male rats and compared to the quercetin as an aldose reductase inhibitor and acarbose as an
C Gonindard et al.
Cell biology and toxicology, 13(3), 141-153 (1997-03-01)
The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree of purity (checked by 1H and 13C NMR spectroscopy)
Alvaro Macias et al.
International journal of molecular sciences, 22(3) (2021-02-13)
KV1.5 channel function is modified by different regulatory subunits. KVβ1.3 subunits assemble with KV1.5 channels and induce a fast and incomplete inactivation. Inhibition of PKC abolishes the KVβ1.3-induced fast inactivation, decreases the amplitude of the current KV1.5-KVβ1.3 and modifies their
Sirosh M Bokhari et al.
The Journal of investigative dermatology, 126(2), 460-467 (2005-12-24)
Activation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cells that affect major functions of the microvasculature. These functions include the first stages of sprouting in angiogenesis, cell migration following wounding, and vascular permeability.
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica