H5042

Cytochrome P450 3A4 human

recombinant, expressed in E. coli

• Sinônimo(s): Cytochrome P450, purified, soluble, 1,4-cineole 2-exo-monooxygenase, Albendazole sulfoxidase, CYP3A3, CYP3A4, Cytochrome P450 NF-25, Cytochrome P450-PCN1
• Número CAS: 9035-51-2
• Código UNSPSC: 12352204
• NACRES: NA.54

Propriedades

• fonte biológica: human
• Nível de qualidade: 200
• recombinante: expressed in E. coli
• descrição: purified, soluble
• Ensaio: 3.5—25 mg protein/mL (Bradford)
• forma: liquid
• atividade específica: 12-200 units/mg protein
• peso molecular: 57318.7 g/mol
• concentração: 3.5-25 mg protein/mL (protein); 50-150 nmol/mL (P450); 6-14 nmol/mg protein (specific content)
• técnica(s): cell based assay: suitable
• solubilidade: water: soluble
• nº de adesão NCBI: NP_059488.2
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... CYP3A4(1576)

Descrição

Descrição geral

Research area: IMMUNO AND CKS

Cytochrome P450 3A4 (CYP3A4) indicates a mammalian enzyme (CYP) family 3, subfamily A, gene 4. There are 57 CYP genes and 33 pseudogenes in humans, organized into 18 families and 42 subfamilies. Among these, the 3A4 isoform (CYP3A4) is the most prevalent and is primarily found in the liver and gastrointestinal tract.

Aplicação

Cytochrome P450 3A4 human has been used in circular dichroism analysis.

Ações bioquímicas/fisiológicas

Cytochrome P450 3A4 (CYP3A4) is one of the isoforms of cytochrome P450 (P450s). Cytochrome P450s (P450s) plays a vital role in processing endogenous compounds and xenobiotics, including pollutants, environmental compounds, and drug molecules. CYP3A4 oxidizes more than 90% of marketed drugs through various metabolic processes.CYP3A4 mRNA expression is upregulated in pediatric Crohn’s disease. Moreover, it provides high tolerance against herbicides such as mefenacet, amiprofos-methyl, pyributicarb, norflurazon, trifluralin, pendimethalin, chlorotoluron, and chloroacetamides.

Definição da unidade

One unit will convert 1.0 nanomole of testosterone to 6-beta-testosterone per minute at pH 7.4 at 37 °C.

Outras notas

Supplied as purified soluble proteins, rather than microsomal preparations.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable