G117

Glipizide

solid

• Sinônimo(s): 1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea
• Fórmula empírica (Notação de Hill): C₂₁H₂₇N₅O₄S
• Número CAS: 29094-61-9
• Peso molecular: 445.54
• Número CE: 249-427-6
• Número MDL: MFCD00072159
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277839
• NACRES: NA.77

Propriedades

• Formulário: solid
• Nível de qualidade: 100
• cor: white
• solubilidade: methanol: 1.9 mg/mL; DMSO: 48 mg/mL
• cadeia de caracteres SMILES: Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
• InChI: 1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
• chave InChI: ZJJXGWJIGJFDTL-UHFFFAOYSA-N
• Informações sobre genes: human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

Descrição

Descrição geral

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1). Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

Aplicação

Glipizide has been used in:

• chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay
• MCF-7 breast cancer assay on chorioallantoic membrane (CAM)
• metastasis assays
• rat aortic ring assay
• in vivo matrigel plug assay
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
• flow cytometry
• western blotting

Ações bioquímicas/fisiológicas

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance. It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC). Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes. Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)