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F6020

Sigma-Aldrich

Fenofibrate

≥99% (TLC), powder, PPARα agonist

Sinônimo(s):

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester

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About This Item

Fórmula empírica (Notação de Hill):
C20H21ClO4
Número CAS:
49562-28-9
Peso molecular:
360.83
Número CE:
256-376-3
Número MDL:
MFCD00133314
Código UNSPSC:
12352200
ID de substância PubChem:
24278015
NACRES:
NA.77

Nome do produto

Fenofibrate, ≥99%, powder

Ensaio

≥99%

Formulário

powder

cor

off-white

originador

Abbott

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2

InChI

1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

chave InChI

YMTINGFKWWXKFG-UHFFFAOYSA-N

Informações sobre genes

human ... PPARA(5465)

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Categorias relacionadas

Aplicação

Fenofibrate has been used:
  • to study its effect on plasma lipids, liver phenotype and gene expression
  • to study its impact on endothelium-dependent vasodilatation of thoracic aorta
  • to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect

Ações bioquímicas/fisiológicas

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.

Características e benefícios

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Warning

Frases de perigo

H373

Declarações de precaução

P260 - P314 - P501

Classificações de perigo

STOT RE 2 Oral

Órgãos-alvo

Liver

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCCB4083
BCBQ5856V
BCBQ5856
BCBL6261V
BCBL6261

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Bezafibrate European Pharmacopoeia (EP) Reference Standard

B1115000

Bezafibrate

Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates
Shiri-Sverdlov R, et al.
Journal of Hepatology, 44(4), 732-741 (2006)
Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
Wouters K, et al.
Febs Letters, 584(5), 1001-1005 (2010)
Oshri Avraham et al.
eLife, 10 (2021-09-30)
Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to study axon regeneration. Whereas regeneration and functional recovery occurs after peripheral nerve injury, spinal cord injury or dorsal root injury is not followed by regenerative
Kristiaan Wouters et al.
FEBS letters, 584(5), 1001-1005 (2010-02-02)
Hepatic inflammation is the key factor in non-alcoholic steatohepatitis (NASH) and promotes progression to liver damage. We recently identified dietary cholesterol as the cause of hepatic inflammation in hyperlipidemic mice. We now show that hepatic transcriptome responses are strongly dependent
Fenofibrate
Keating GM and Croom KF
Drugs, 67(1), 121?153-121?153 (2012)
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