D5782
2′,3′-Dideoxycytidine
≥98% (HPLC)
Sinônimo(s):
ddC
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About This Item
Fórmula empírica (Notação de Hill):
C9H13N3O3
Número CAS:
Peso molecular:
211.22
Beilstein:
654956
Número MDL:
Código UNSPSC:
41106305
ID de substância PubChem:
NACRES:
NA.52
Produtos recomendados
fonte biológica
synthetic (organic)
Ensaio
≥98% (HPLC)
Formulário
powder
cor
colorless
pf
217-218 °C (lit.)
solubilidade
water: 50 mg/mL, clear, colorless to faintly yellow
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](CO)O2
InChI
1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1
chave InChI
WREGKURFCTUGRC-POYBYMJQSA-N
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Aplicação
2′,3′-Dideoxycytidine is used:
- as a DNA chain-terminating nucleotide for DNA sequencing methods based on the Sanger chain-termination method
- as a nucleoside reverse transcriptase inhibitor (NRTI) to study its effects on the development of mechanical allodynia in aging mice
- as a mitochondrial DNA (mtDNA) replication inhibitor to inhibit the activation of cGAS-STING pathway and study its effects on signaling protein-stimulator of interferon genes (STING), cyclic GMP-AMP synthase (cGAS), and phospho-interferon regulator factor 3 (p-IRF3) expression in mouse hippocampal and microglial cells
- as an NRTI inhibitor to study its effects on the drug induced-mitochondrial toxicity in Caenorhabditis elegans
Ações bioquímicas/fisiológicas
2′,3′-Dideoxycytidine (ddC), is an ionic compound and a nucleoside analog. It acts as a nucleoside reverse transcriptase inhibitor and exhibits therapeutic effects against human immunodeficiency virus (HIV) infection. 2′,3′-Dideoxycytidine possesses anti-adenovirus activity and inhibits the adenovirus polymerase.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Carc. 2
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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