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D1387

Sigma-Aldrich

P1,P3-Di(adenosine-5′) triphosphate ammonium salt

Sinônimo(s):

A(5′)P3(5′)A, Diadenosine triphosphate

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About This Item

Fórmula linear:
C20H24N9O16P3 · NH3
Número CAS:
102783-40-4
Peso molecular:
756.41
Número MDL:
MFCD00058130
Código UNSPSC:
41106305
eCl@ss:
32160414
ID de substância PubChem:
24893423
NACRES:
NA.51

forma

solid

Impurezas

Other adenosine phosphates, essentially free

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

N.Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(=O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)C(O)C3O

InChI

1S/C20H27N10O16P3.H3N/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(43-19)1-41-47(35,36)45-49(39,40)46-48(37,38)42-2-8-12(32)14(34)20(44-8)30-6-28-10-16(22)24-4-26-18(10)30;/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H2,21,23,25)(H2,22,24,26);1H3

chave InChI

PKSQTRWRSNNYCW-UHFFFAOYSA-N

Categorias relacionadas

Aplicação

P1,P3-Di(adenosine-5′) triphosphate (Ap3A) is a diadenosine oligophosphate (ApnA) family member. ApnAs have been found to act as a signaling molecule.
P1,P3-Di(adenosine-5′) triphosphate ammonium salt has been used as a component of the incubation medium for incubating fibroblast cell lines for FoF1 ATP-synthase activity.

Quantidade

Approx. 25 A260 units per mg.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Michael Wright et al.
The FEBS journal, 273(15), 3534-3544 (2006-08-04)
Heat shock inducible lysyl-tRNA synthetase of Escherichia coli (LysU) is known to be a highly efficient diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) synthase. However, we use an ion-exchange HPLC technique to demonstrate that active LysU mixtures actually have a dual catalytic activity, initially
A S Mildvan et al.
Archives of biochemistry and biophysics, 433(1), 129-143 (2004-12-08)
Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties, X, and contain the sequence motif or Nudix box, GX(5)EX(7)REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate at which nucleophilic substitution
Alan R Conant et al.
Vascular pharmacology, 48(4-6), 157-164 (2008-03-08)
Diadenosine polyphosphates (Ap(n)A) are released by degranulating platelets and high, local concentrations may form at sites of platelet activation. Radial artery grafts, now often used alongside the internal mammary artery in coronary artery bypass surgery, are particularly reactive to several
Brigitte Maria Stavrou
Current medicinal chemistry. Cardiovascular and hematological agents, 1(2), 151-169 (2004-08-24)
Diadenosine polyphosphates (Ap(n)A) are naturally occurring molecules which have been identified in human and guinea-pig cardiac tissue and whose physiological role is being established. They are stored in platelet dense granules in a metabolically inactive form. Ap(n)A form a class
Manuela Campiglio et al.
Journal of cellular physiology, 208(2), 274-281 (2006-03-21)
FHIT is a tumor suppressor gene that is frequently inactivated in human cancer. Although the Fhit protein is known to hydrolyze diadenosine triphosphate (Ap(3)A), this hydrolase activity is not required for Fhit-mediated oncosuppression. Indeed, the molecular mechanisms and the regulatory
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