C9872
Anti-CIRBP (121-135) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Sinônimo(s):
Anti-CIRP, Anti-Cold-inducible RNA-binding protein
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
conjugado:
unconjugated
application:
WB
clone:
polyclonal
reatividade de espécies:
human
citations:
3
técnica(s):
western blot: 1:500-1:2,000
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
IgG fraction of antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
antigen ~19 kDa
reatividade de espécies
human
técnica(s)
western blot: 1:500-1:2,000
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CIRBP(1153)
Descrição geral
CIRBP is expressed in normal testes and downregulated after heat stress caused by cryptorchidism, varicocele or environmental temperatures.
Imunogênio
synthetic peptide corresponding to amino acids 121-135 of human CIRBP
Aplicação
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CIRBP antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2000.
Ações bioquímicas/fisiológicas
Extracellular CIRBP is a detrimental factor in stimulating inflammation to cause neuronal damage in cerebral ischemia. It may have a protective effect on testicular injury after testicular torsion/detorsion when upregulated. Downregulation of CIRBP has been shown to increase germ cell apoptosis.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Zhiping Xia et al.
Journal of pediatric surgery, 48(10), 2140-2147 (2013-10-08)
To evaluate the expression of Cold-inducible RNA-binding protein (CIRP) in torsion/detorsion of the testes in different phases and demonstrate the protective effect of CIRP on testicular injury after torsion/detorsion (T/D) in an experimental mouse model. Twenty-four male BALB/c mice were
Zhi-Ping Xia et al.
Asian journal of andrology, 14(6), 884-889 (2012-09-25)
Cold-inducible RNA-binding protein (CIRP) is an RNA-binding protein that is expressed in normal testes and downregulated after heat stress caused by cryptorchidism, varicocele or environmental temperatures. The purpose of this study was to investigate the functions of CIRP in the
Wen Hao Ren et al.
Medical oncology (Northwood, London, England), 31(8), 120-120 (2014-07-17)
Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Here, we evaluated the expression of cold-inducible RNA-binding protein (CIRP) and toll-like receptors 4 (TLR4) in OSCC tissues with immunohistochemistry. Using biostatistical methods designed to assess the
Mian Zhou et al.
Biochimica et biophysica acta, 1840(7), 2253-2261 (2014-03-13)
Neuroinflammation is a key cascade after cerebral ischemia. Excessive production of proinflammatory mediators in ischemia exacerbates brain injury. Cold-inducible RNA-binding protein (CIRP) is a newly discovered proinflammatory mediator that can be released into the circulation during hemorrhage or septic shock.
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