C5624

Cryptotanshinone

≥98% (HPLC)

• Sinônimo(s): 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione, Cryptotanshinon, Tanshinone c
• Fórmula empírica (Notação de Hill): C₁₉H₂₀O₃
• Número CAS: 35825-57-1
• Peso molecular: 296.36
• Número MDL: MFCD07636810
• Código UNSPSC: 12352200
• ID de substância PubChem: 329775097
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• atividade óptica: [α]/D -80 to -99°, c = 0.5 in chloroform-d
• condição de armazenamento: desiccated; protect from light
• cor: orange-brown
• solubilidade: DMSO: ≥5 mg/mL
• aplicação(ões): metabolomics; vitamins, nutraceuticals, and natural products
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23
• InChI: 1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
• chave InChI: GVKKJJOMQCNPGB-JTQLQIEISA-N

Descrição

Ações bioquímicas/fisiológicas

Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable