Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

C3116

Sigma-Aldrich

Anti-CXCR4 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Anti-CXC Chemokine Receptor 4

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Número MDL:
MFCD01092337
Código UNSPSC:
51111800

fonte biológica

rabbit

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

reatividade de espécies

human

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 9-14 μg/mL

nº de adesão UniProt

P61073

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CXCR4(7852)
mouse ... Cxcr4(12767)
rat ... Cxcr4(60628)

Imunogênio

synthetic peptide corresponding to the third cytoplasmic loop of human CXC chemokine receptor 4 (CXCR4), conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.

Aplicação

Anti-CXCR4 antibody produced in rabbit is suitable for immunohistochemistry of formalin-fixed, paraffin-embedded tissue sections at a working concentration of 9-14 μg/mL. It was used to stain rat bladder sections at a dilution of 1:2000, incubated overnight.

Ações bioquímicas/fisiológicas

CXCR4 is a cell surface receptor of the chemokine CXCL12 (SDF-1) and is involved in metastasis, hematopoiesis and immune responses. It acts with CD4 to facilitate the entry of HIV into target cells. CXCR4 has important roles in tumor initiation, proliferation, invasion and metastasis of breast cancer cells.

forma física

Solution in phosphate buffered saline, containing 0.1% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Não está encontrando o produto certo?  

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

M J Walters et al.
British journal of cancer, 110(5), 1179-1188 (2014-01-16)
In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes tumour recurrence. The role of CXCR7, the high-affinity receptor for CXCL12, in the tumour's response to IR has not been addressed. We
Angelo Ferrari et al.
BMC veterinary research, 8, 27-27 (2012-03-16)
Mammary tumours frequently develop in female domestic cats being highly malignant in a large percentage of cases. Chemokines regulate many physiological and pathological processes including organogenesis, chemotaxis of inflammatory cells, as well as tumour progression and metastasization. In particular, the
Pedro L Vera et al.
PloS one, 3(12), e3898-e3898 (2008-12-11)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro. We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis. Twenty male
Max Yan et al.
Breast cancer research : BCR, 13(2), R47-R47 (2011-04-28)
Basal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg. Immunoperoxidase
Bikash Debnath et al.
Theranostics, 3(1), 47-75 (2013-02-06)
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases, such as HIV, cancer, WHIM syndrome, rheumatoid arthritis, pulmonary fibrosis and lupus. For
Exibir todos os documentos relacionados

Artigos

Cancer Stem Cells: Targets for Cancer Therapy

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica