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C1240

Sigma-Aldrich

Chlormethiazole hydrochloride

≥98% (HPLC), powder

Sinônimo(s):

4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C6H8ClNS · HCl
Número CAS:
6001-74-7
Peso molecular:
198.11
Número MDL:
MFCD00673948
Código UNSPSC:
12352200
ID de substância PubChem:
329774745
NACRES:
NA.77

descrição

Store desiccated

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

off-white

solubilidade

H2O: soluble >10 mg/mL

originador

AstraZeneca

cadeia de caracteres SMILES

Cl.Cc1ncsc1CCCl

InChI

1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H

chave InChI

OFXYKSLKNMTBHK-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.
GABAA agonist; glycine receptor modulator.

Características e benefícios

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Frases de perigo

H302,H317,H318

Classificações de perigo

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
034M4611V
031M4623V
087K46314
087K46313
087K46312

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A Nurse's Survival Guide to Acute Medical Emergencies (2011)
Koichi Nisijima et al.
Neurochemistry international, 43(2), 155-164 (2003-03-07)
The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT syndrome by intraperitoneally injecting rats with clorgyline (2 mg/kg)
Pediatric Critical Care Medicine: Basic Science And Clinical Evidence, 985-985 (2007)
Rachael M Nelson et al.
European journal of pharmacology, 452(3), 255-262 (2002-10-03)
Clomethiazole is a gamma-aminobutyric acid (GABA)-mimetic agent with anticonvulsant, sedative and neuroprotective properties. The pharmacological actions of clomethiazole that underlie its functional profile have not been fully explored, but are known to result from an interaction with the GABA(A) receptor.
M Gasior et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 153-161 (2000-09-19)
Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experimental and clinical studies reporting effectiveness against the toxic effects
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