C0158
L-Carnitine inner salt
≥98%
Sinônimo(s):
(−)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate, Vitamin BT
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About This Item
Fórmula linear:
(CH3)3N+CH2CH(OH)CH2COO-
Número CAS:
Peso molecular:
161.20
Beilstein:
4292315
Número CE:
Número MDL:
Código UNSPSC:
12352209
ID de substância PubChem:
NACRES:
NA.79
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Nome do produto
L-Carnitine inner salt, synthetic, ≥98%
fonte biológica
synthetic
Nível de qualidade
Ensaio
≥98%
Formulário
powder
cor
white
pf
197-212 °C (lit.)
aplicação(ões)
cell analysis
detection
cadeia de caracteres SMILES
C[N+](C)(C)C[C@H](O)CC([O-])=O
InChI
1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
chave InChI
PHIQHXFUZVPYII-ZCFIWIBFSA-N
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Aplicação
L-Carnitine inner salt has been used as a component of an assay medium for Seahorse XF mitochondrial stress assay. It has also been orally administered to tumor-bearing mice, in order to study its effect on the regulation of peroxisome proliferator-activated receptor and thereby to analyse liver inflammatory response.
Ações bioquímicas/fisiológicas
Carnitine biosynthesized from lysine. Carnitine facilitates fatty acid transport into the mitochondrial compartment. In skeletal and cardiac muscle tissue it acts as a metabolic cofactor. Carnitine might be associated with the energy production from branched chain amino acids.
Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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Sunil K Panchal et al.
Food & function, 6(8), 2496-2506 (2015-07-21)
Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular
L-carnitine ameliorates the liver inflammatory response by regulating carnitine palmitoyltransferase I-dependent PPAR? signaling
Fang Jiang
Molecular Medicine Reports, 13(2) (2015)
Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles
Rui Li
The Journal of Physiology, 594(24), 7197-7213 (2016)
N A Oey et al.
Placenta, 27(8), 841-846 (2005-11-23)
Carnitine plays an indispensable role in fatty acid oxidation. Previous studies revealed that fetal carnitine is derived from the mother via transplacental transfer. Recent studies demonstrated the presence and importance of an active fatty acid oxidation system in the human
Andrea Lenzi et al.
Fertility and sterility, 81(6), 1578-1584 (2004-06-15)
To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. Placebo-controlled double-blind randomized trial. University tertiary referral center. Sixty infertile patients (aged 20-40 years) with the following baseline sperm selection criteria: concentration, 10 to 40
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