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B2682

Sigma-Aldrich

Boc-Asp(OMe)-fluoromethyl ketone

≥90% (TLC), solid

Sinônimo(s):

Boc-D-FMK

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About This Item

Fórmula empírica (Notação de Hill):
C11H18NO5F
Número CAS:
187389-53-3
Peso molecular:
263.26
Número MDL:
MFCD03453073
Código UNSPSC:
12352209
ID de substância PubChem:
329773206
NACRES:
NA.77

Ensaio

≥90% (TLC)

forma

solid

solubilidade

DMF: soluble

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF

InChI

1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1

chave InChI

MXOOUCRHWJYCAL-ZETCQYMHSA-N

Aplicação

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

Ações bioquímicas/fisiológicas

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H319

Classificações de perigo

Eye Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Y M Chan et al.
Neuroreport, 12(3), 541-545 (2001-03-10)
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Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes
Deas O, et al.
Journal of immunology (Baltimore, Md. : 1950), 161(7), 3375-3383 (1998)
Broad-spectrum caspase inhibitors: from myth to reality?
Chauvier D, et al.
Cell Death and Differentiation, 14(2), 387-391 (2007)
Qiruo Gao et al.
Cell biochemistry and biophysics, 70(1), 461-465 (2014-05-06)
Adiponectin, an adipose tissue-derived hormone, has been studied intensively for the past decade because of its anti-inflammatory, anti-atherogenic, and anti-diabetic properties. Recent advances suggest that adiponectin also plays an important role in the development and progression of various cancers. Accumulating
Heat-induced programmed cell death in Leishmania infantum is reverted by Bcl-X L expression
Alzate JF, et al.
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