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A5855

Sigma-Aldrich

Abz-LFK(Dnp)-OH trifluoroacetate salt

≥97% (HPLC)

Sinônimo(s):

O-Aminobenzoic acid-Leu-Phe-Lys(DNP)-OH trifluoroacetate salt

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About This Item

Fórmula empírica (Notação de Hill):
C34H41N7O9 · xC2HF3O2
Peso molecular:
691.73 (free base basis)
Número MDL:
MFCD11045275
Código UNSPSC:
12352200
ID de substância PubChem:
329770877
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥97% (HPLC)

forma

film

cor

yellow

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)c1ccccc1N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCNc3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)C(O)=O

InChI

1S/C34H41N7O9.C2HF3O2/c1-21(2)18-28(38-31(42)24-12-6-7-13-25(24)35)32(43)39-29(19-22-10-4-3-5-11-22)33(44)37-27(34(45)46)14-8-9-17-36-26-16-15-23(40(47)48)20-30(26)41(49)50;3-2(4,5)1(6)7/h3-7,10-13,15-16,20-21,27-29,36H,8-9,14,17-19,35H2,1-2H3,(H,37,44)(H,38,42)(H,39,43)(H,45,46);(H,6,7)/t27-,28-,29-;/m0./s1

chave InChI

BAXBDLHYKKDHEJ-BJRQXHFHSA-N

Amino Acid Sequence

Abz-Leu-Phe-Lys-DNP

Aplicação

Abz-LFK(Dnp)-OH trifluoroacetate (TFA) salt is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate that binds specifically to the C domain of ACE. Abz-LFK(Dnp)-OH TFA has been used to study the development of new antibacterial calixarene derivatives, as well as the efficacy and toxicity of the antimicrobial peptide M33 as a possible antimicrobial agent in lung infections and sepsis.

Ações bioquímicas/fisiológicas

Abz-LFK(Dnp)-OH is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate specific for the C domain for real time fluorescent assay (ACE, Peptidyl Dipeptidase, Kininase II, E.C. 3.4.15.1).

Características e benefícios

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Alessandro Pini et al.
Amino acids, 43(1), 467-473 (2011-10-11)
The tetra-branched peptide M33 (Pini et al. in FASEB J 24:1015-1022, 2010) is under evaluation in animal models for its activity as antimicrobial agent in lung infections and sepsis. The preclinical development of a new drug requires medium-scale manufacture for
L-arginine trifluoroacetate salt bridges in its solid state compound: the low-temperature three dimensional structural determination of L-arginine bis(trifluoroacetate) crystal and its vibrational spectral analysis
Sun, Z.H., et al.
Spectrochimica Acta Part A: Molecular Spectroscopy, 83, 39-45 (2011)
Guillaume Sautrey et al.
The journal of physical chemistry. B, 115(50), 15002-15012 (2011-11-16)
Tetra-p-guanidinoethylcalix[4]arene trifluoroacetate salt (CX1) was synthesized recently as an antibacterial agent. It showed to be active in vitro against various Gram-positive and Gram-negative bacteria. To get more insight in the mechanism of the biological activity of this derivative, it was

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