A265

ARL 67156 trisodium salt hydrate

≥98% (HPLC), solid, ecto-ATPase inhibitor

• Sinônimo(s): 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate trisodium salt hydrate, FPL 67156
• Fórmula empírica (Notação de Hill): C₁₅H₂₁Br₂N₅Na₃O₁₂P₃ · xH₂O
• Número CAS: 160928-38-1
• Peso molecular: 785.05 (anhydrous basis)
• Número MDL: MFCD12910436
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278252
• NACRES: NA.77

Propriedades

• Nome do produto: ARL 67156 trisodium salt hydrate, ≥98% (HPLC), solid
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• cor: white to off-white
• solubilidade: H₂O: >20 mg/mL; DMSO: insoluble
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
• chave InChI: UWMONIJVKGTUGE-OPKBHZIBSA-K
• Informações sobre genes: human ... ENTPD2(954)

Descrição

Descrição geral

ARL 67156, a nucleotide/ATP analog is a competitive inhibitor of CD39. This ecto-ATPase inhibitor is presumed to be metabolically stable in biological studies due to its β, γ-dibromomethylene bridge.

ARL-67156 preferentially inhibits the degradation of ADP compared to the degradation of ATP in the murine colon. It is commonly employed to inhibit ATP hydrolysis in tissue preparations.

Aplicação

ARL 67156 trisodium salt hydrate has been used:

• to prevent ATP degradation during cerebrospinal fluid extraction
• as an ATPase inhibitor in ATP quantification assay for preventing ATP degradation in cytoplasm and mitochondrion
• as an ecto-ATPase inhibitor to treat cancer cells for ATP release assay

Ações bioquímicas/fisiológicas

ecto-ATPase inhibitor; prevents metabolism of P₂ purinoceptor agonists.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3