A0132

Atropine

≥99% (TLC), powder

• Sinônimo(s): Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
• Fórmula empírica (Notação de Hill): C₁₇H₂₃NO₃
• Número CAS: 51-55-8
• Peso molecular: 289.37
• Beilstein: 91260
• Número CE: 200-104-8
• Número MDL: MFCD00022622
• Código UNSPSC: 41116107
• ID de substância PubChem: 24890401
• NACRES: NA.77

Propriedades

• Ensaio: ≥99% (TLC)
• forma: powder
• cor: white
• solubilidade: H₂O: 2 mg/mL; dilute aqueous acid: soluble; ethanol: soluble
• cadeia de caracteres SMILES: CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
• InChI: 1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
• chave InChI: RKUNBYITZUJHSG-SPUOUPEWSA-N
• Informações sobre genes: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , LOC730413(730413) ; mouse ... Chrm1(12669) ; rat ... Chrm1(25229) , Chrm2(81645) , Chrm3(24260) , Drd2(24318) , Htr1a(24473)

Descrição

Descrição geral

Atropine, a belladonna alkaloid, is an anti-muscarinic drug. It is extracted from Atropa belladonna. Atropine is an anticholinergic agent, which is linked to passive mydriasis. It blocks acetylcholine receptors in brain and has hallucinogenic effects. Atropine eye drops are used to treat uveitis and early amblyopia. It is also used to treat nerve agents.

Aplicação

Atropine has been used to study it′s in vitro cytotoxicity, antiviral and antimicrobial activities. It has also used to antagonize acetylcholine induced K⁺ current.

Atropine has been used:

• as a tastant to analyse the bitter taste perception in Drosophila larvae
• as a muscarinic acetylcholine autoreceptors (mAChRs) antagonist to investigate the involvement of individual mAChR subtypes in the control of synapse elimination
• to investigate the pathways of serotonin (5-HT) action in zebrafish hearts

Ações bioquímicas/fisiológicas

Atropine is used to treat myopia and ocular axial elongation in Asian children. Small dosage of atropine is used to slow down the heart rate.

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Características e benefícios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Reconstituição

Solutions stable for several days at 4 °C.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300 + H330
• Declarações de precaução: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Classificações de perigo: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges