94581
Hirudin recombinant from yeast
lyophilized powder, white, >1500 U/vial
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About This Item
Produtos recomendados
fonte biológica
synthetic
yeast (Pichia pastoris)
forma
lyophilized powder
atividade específica
>1500 U/vial
peso molecular
Mr ~6963.5
cor
white
solubilidade
0.1 M Tris, 0.2 M NaCl, pH 8.4: 1 vial/mL, clear, colorless
temperatura de armazenamento
−20°C
Aplicação
Recombinant hirudin from yeast has been used in mannan-binding lectin serine protease 2 (MASP2) activation assay. It has also been used in pre-treating the nanosheets in phosphate buffered saline (PBS) for platelet adhesion assay.
Ações bioquímicas/fisiológicas
Recombinant hirudin appears to be antigenic. Independent studies have found that 50-70% of patients treated for several days with recombinant hirudin develop at least one hirudin antibody isotype. The antibodies reduce the anticoagulant effect of hirudin, but prolong its plasma half-life by reducing renal filtration.
The anticoagulant, hirudin, is the most potent natural inhibitor of both soluble and clot-bound thrombin. It binds thrombin with high affinity, covering more than 20% of its surface area and occluding both the active site and exosite I (fibrinogen and PAR recognition site). Hirudin blocks thrombus growth and platelet activation. It is not metabolized in the bloodstream of humans and is eliminated unchanged via kidney filtration.
Definição da unidade
1 U corresponds to 1 ATU (antithrombin unit; 1 ATU is defined as the amount of inhibitor that neutralizes 1 NIH unit of thrombin).
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
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Volker Liebe et al.
Seminars in thrombosis and hemostasis, 28(5), 483-490 (2002-11-07)
This article provides an overview of the clinically relevant characteristics of antibodies directed toward recombinant (r) hirudin, with emphasis on the different ways in which these antibodies may influence pharmacokinetics and pharmacodynamics of r-hirudin. A high incidence of anti-hirudin antibody
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Carroll MV, et al.
Molecular Immunology, 46(16), 3367-3378 (2009)
A few immobilized thrombins are sufficient for platelet spreading
Okamura Y, et al.
Biophysical Journal, 100(8), 1855-1863 (2011)
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