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Key Documents

Outros documentos

80424

Sigma-Aldrich

Di(N-succinimidyl) glutarate

≥97.0% (CHN)

Sinônimo(s):

DSG

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About This Item

Fórmula empírica (Notação de Hill):
C13H14N2O8
Número CAS:
79642-50-5
Peso molecular:
326.26
Beilstein:
8575145
Número MDL:
MFCD00153597
Código UNSPSC:
12161502
ID de substância PubChem:
57652832
NACRES:
NA.25

Nível de qualidade

100

Ensaio

≥97.0% (CHN)

forma

lumps

adequação da reação

reagent type: cross-linking reagent

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O=C(CCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O

InChI

1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2

chave InChI

LNQHREYHFRFJAU-UHFFFAOYSA-N

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

Homobifunctional cross-linking reagent; e.g. isolation of insulin receptor

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315 - H319 - H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol 2,000

Sigma-Aldrich

713783

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol

DSG-PEG 2000 Avanti Polar Lipids

Avanti

880152P

DSG-PEG 2000

N,N′-Disuccinimidyl carbonate purum, ≥95.0% (NMR)

Sigma-Aldrich

43720

N,N′-Disuccinimidyl carbonate

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Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with the hematopoietic master regulator RUNX1. We previously showed that the maintenance of
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TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with amyotrophic lateral sclerosis and frontotemporal dementia. Here, we report that physiological nuclear TDP-43 in mouse and human brain forms homo-oligomers that
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