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59815

Sigma-Aldrich

1-(4-Isothiocyanatobenzyl)ethylenediamine-N,N,N′,N′-tetraacetic acid

~90% (HPLC)

Sinônimo(s):

Isothiocyanatobenzyl-EDTA

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About This Item

Fórmula empírica (Notação de Hill):
C18H21N3O8S
Número CAS:
105394-74-9
Peso molecular:
439.44
Beilstein:
8363400
Número MDL:
MFCD00236411
Código UNSPSC:
12352106
ID de substância PubChem:
57651699
NACRES:
NA.25

Ensaio

~90% (HPLC)

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC(=O)CN(CC(Cc1ccc(cc1)N=C=S)N(CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C18H21N3O8S/c22-15(23)7-20(8-16(24)25)6-14(21(9-17(26)27)10-18(28)29)5-12-1-3-13(4-2-12)19-11-30/h1-4,14H,5-10H2,(H,22,23)(H,24,25)(H,26,27)(H,28,29)

chave InChI

VHMWJVAFPCGUTJ-UHFFFAOYSA-N

Aplicação

Isothiocyanatobenzyl-EDTA is a bifunctional chelator used in bioconjugation chemistry to label primary amine containing molecules and proteins preferentially at their N-terminals.

Outras notas

Amine-reactive probe, useful for antibody chelate labeling

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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T M Rana et al.
Bioconjugate chemistry, 1(5), 357-362 (1990-09-01)
Conjugates of monoclonal antibodies with drugs, toxins, radionuclides, and other agents are in widespread use in therapeutic trials and as clinical research tools. The characterization of these immunoconjugates generally does not include determining the individual sites at which such agents
S V Deshpande et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 31(2), 218-224 (1990-02-01)
The metabolism of radiolabeled antibodies is important for radioimmunoimaging and therapy. The loss of indium-111 (111In) from the chelate can pose problems in imaging and increases the radiation dose to normal tissues. We have evaluated the loss in vivo of
K Shah et al.
Bioconjugate chemistry, 7(3), 283-289 (1996-05-01)
The synthesis of a C-5 modified uridine phosphoramidite which contains a primary amino group protected with Fmoc is described. During cleavage and deprotection of chemically synthesized RNA, the Fmoc protecting group is removed to yield a free amino group at
Z Yao et al.
Nuclear medicine and biology, 22(2), 199-203 (1995-02-01)
Tn antigen is a glycosylated tumor associated antigen and a murine monoclonal antibody, MLS128, has been identified to react with it. The potential of MLS128 for the radioimmunoimaging of colorectal cancer was studied. MLS128 was labeled with radioiodine by the

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