477R-1

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

• Sinônimo(s): Melanoma-associated antigen C2
• Código UNSPSC: 12352203
• clone: EP405, monoclonal
• application: IHC (p)
• reatividade de espécies: human
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• citations: 7

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100; 500
• conjugado: unconjugated
• forma do anticorpo: culture supernatant
• tipo de produto de anticorpo: primary antibodies
• clone: EP405, monoclonal
• descrição: For In Vitro Diagnostic Use in Select Regions
• Formulário: buffered aqueous solution
• reatividade de espécies: human
• embalagem: vial of 0.1 mL concentrate (477R-14); vial of 0.1 mL concentrate Research Use Only (477R-14-RUO); vial of 0.5 mL concentrate (477R-15); vial of 1.0 mL concentrate (477R-16); vial of 1.0 mL concentrate Research Use Only (477R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (477R-17); vial of 7.0 mL pre-dilute ready-to-use (477R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)
• fabricante/nome comercial: Cell Marque^™
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• Isotipo: IgG
• controle: seminoma
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• visualização: nuclear

Descrição

Descrição geral

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.^1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.⁴ In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.^5-7

Qualidade

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparo

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Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable